血液净化技术在严重发热伴血小板减少综合征中的应用。

IF 6.5 3区 工程技术 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Biotechnology & Genetic Engineering Reviews Pub Date : 2024-12-01 Epub Date: 2023-05-30 DOI:10.1080/02648725.2023.2219940
Hongxia Gao, Baoyin Wang, Hui Yao, Wenjie Zhang, HaiFeng Teng
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引用次数: 0

摘要

摘 要本文旨在总结血液净化技术应用于重症发热伴血小板减少综合征(SFTS)患者的临床治疗效果:回顾性分析山东大学附属威海市立医院2014年5月-2019年11月收治的96例重症SFTS患者的病历资料,将其分为生存组和死亡组。对两组患者入重症监护室(ICU)期间基本资料检测指标、治疗方法选择等方面的差异进行显著性分析,并将差异具有统计学意义的指标纳入预后相关的多变量Logistic回归分析:结果:生存组与死亡组在年龄、性别构成、白细胞计数、血小板计数、肌酸激酶(CK)、活化部分凝血活酶时间(APTT)、血清肌酐和血液滤过肾脏替代治疗等方面差异无统计学意义。两组在病毒载量胆红素以及血浆置换(PE)或血液灌流(HP)治疗方法上存在统计学差异。血浆置换组(78例)、血液滤过组(12例)、血液灌流组(6例)、血浆置换和血液灌流与其他血液净化治疗的预后差异均有统计学意义:结论:与三种血液净化方法相比,血浆置换对重症 SFTS 患者的病毒清除、凝血功能改善和存活率均有显著效果。血液滤过在清除炎症介质、替代肾功能、维持电解质和酸碱平衡方面发挥作用,但在清除病毒方面作用不大。
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Application of blood purification technology in severe fever with thrombocytopenia syndrome.

Objective: The purpose of this paper is to summarize the blood purification technology applied in patients with severe fever with thrombocytopenia syndrome (SFTS) in the clinical treatment effect.

Methods: The medical records of 96 patients with severe SFTS admitted to Weihai Municipal Hospital affiliated to Shandong University from May 2014 to November 2019 were retrospectively analyzed, and they were divided into survival group and death group. The differences in basic data test indexes and treatment method selection during intensive care unit (ICU) admission between the two groups were significantly analyzed, and the indexes with statistically significant differences were included in the multivariate logistic regression analysis related to prognosis.

Results: There were no statistically significant differences in age, sex composition, white blood cell count, platelet count, creatine kinase (CK), activated partial thromboplastin time (APTT), serum creatinine and hemofiltration renal replacement therapy between the survival group and the death group. There were statistically significant differences between the two groups in viral load bilirubin and the treatment methods of plasma exchange (PE) or hemoperfusion (HP). Plasma exchange group (78 cases), hemofiltration group (12 cases), hemoperfusion group (6 cases), plasma exchange and hemoperfusion and other blood purification treatment of the prognosis were statistically different.

Conclusions: Compared with the three blood purification methods, plasmapheresis has a significant effect on virus removal, improvement of coagulation function and survival rate in patients with severe SFTS. Hemofiltration plays a role in removing inflammatory mediators, replacing renal function, maintaining electrolytes and acid-base balance, but not in removing viruses.

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来源期刊
Biotechnology & Genetic Engineering Reviews
Biotechnology & Genetic Engineering Reviews BIOTECHNOLOGY & APPLIED MICROBIOLOGY-GENETICS & HEREDITY
CiteScore
6.50
自引率
3.10%
发文量
33
期刊介绍: Biotechnology & Genetic Engineering Reviews publishes major invited review articles covering important developments in industrial, agricultural and medical applications of biotechnology.
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