VEGF-A血浆水平与长COVID患者的DLCO受损和放射学后遗症有关。

IF 9.2 1区 医学 Q1 PERIPHERAL VASCULAR DISEASE Angiogenesis Pub Date : 2023-08-01 DOI:10.1007/s10456-023-09890-9
Aurélien Philippe, Sven Günther, Jeanne Rancic, Pauline Cavagna, Bertrand Renaud, Nicolas Gendron, Elie Mousseaux, Thông Hua-Huy, Guillaume Reverdito, Benjamin Planquette, Olivier Sanchez, Pascale Gaussem, Dominique Salmon, Jean-Luc Diehl, David M. Smadja
{"title":"VEGF-A血浆水平与长COVID患者的DLCO受损和放射学后遗症有关。","authors":"Aurélien Philippe,&nbsp;Sven Günther,&nbsp;Jeanne Rancic,&nbsp;Pauline Cavagna,&nbsp;Bertrand Renaud,&nbsp;Nicolas Gendron,&nbsp;Elie Mousseaux,&nbsp;Thông Hua-Huy,&nbsp;Guillaume Reverdito,&nbsp;Benjamin Planquette,&nbsp;Olivier Sanchez,&nbsp;Pascale Gaussem,&nbsp;Dominique Salmon,&nbsp;Jean-Luc Diehl,&nbsp;David M. Smadja","doi":"10.1007/s10456-023-09890-9","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><p>Long COVID, also known as post-acute sequelae of COVID-19 (PASC), is characterized by persistent clinical symptoms following COVID-19.</p><h3>Objective</h3><p>To correlate biomarkers of endothelial dysfunction with persistent clinical symptoms and pulmonary function defects at distance from COVID-19.</p><h3>Methods</h3><p>Consecutive patients with long COVID-19 suspicion were enrolled. A panel of endothelial biomarkers was measured in each patient during clinical evaluation and pulmonary function test (PFT).</p><h3>Results</h3><p>The study included 137 PASC patients, mostly male (68%), with a median age of 55 years. A total of 194 PFTs were performed between months 3 and 24 after an episode of SARS-CoV-2 infection. We compared biomarkers evaluated in PASC patients with 20 healthy volunteers (HVs) and acute hospitalized COVID-19 patients (<i>n</i> = 88). The study found that angiogenesis-related biomarkers and von Willebrand factor (VWF) levels were increased in PASC patients compared to HVs without increased inflammatory or platelet activation markers. Moreover, VEGF-A and VWF were associated with persistent lung CT scan lesions and impaired diffusing capacity of the lungs for carbon monoxide (DLCO) measurement. By employing a Cox proportional hazards model adjusted for age, sex, and body mass index, we further confirmed the accuracy of VEGF-A and VWF. Following adjustment, VEGF-A emerged as the most significant predictive factor associated with persistent lung CT scan lesions and impaired DLCO measurement.</p><h3>Conclusion</h3><p>VEGF-A is a relevant predictive factor for DLCO impairment and radiological sequelae in PASC. Beyond being a biomarker, we hypothesize that the persistence of angiogenic disorders may contribute to long COVID symptoms.</p></div>","PeriodicalId":7886,"journal":{"name":"Angiogenesis","volume":null,"pages":null},"PeriodicalIF":9.2000,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"VEGF-A plasma levels are associated with impaired DLCO and radiological sequelae in long COVID patients\",\"authors\":\"Aurélien Philippe,&nbsp;Sven Günther,&nbsp;Jeanne Rancic,&nbsp;Pauline Cavagna,&nbsp;Bertrand Renaud,&nbsp;Nicolas Gendron,&nbsp;Elie Mousseaux,&nbsp;Thông Hua-Huy,&nbsp;Guillaume Reverdito,&nbsp;Benjamin Planquette,&nbsp;Olivier Sanchez,&nbsp;Pascale Gaussem,&nbsp;Dominique Salmon,&nbsp;Jean-Luc Diehl,&nbsp;David M. Smadja\",\"doi\":\"10.1007/s10456-023-09890-9\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><p>Long COVID, also known as post-acute sequelae of COVID-19 (PASC), is characterized by persistent clinical symptoms following COVID-19.</p><h3>Objective</h3><p>To correlate biomarkers of endothelial dysfunction with persistent clinical symptoms and pulmonary function defects at distance from COVID-19.</p><h3>Methods</h3><p>Consecutive patients with long COVID-19 suspicion were enrolled. A panel of endothelial biomarkers was measured in each patient during clinical evaluation and pulmonary function test (PFT).</p><h3>Results</h3><p>The study included 137 PASC patients, mostly male (68%), with a median age of 55 years. A total of 194 PFTs were performed between months 3 and 24 after an episode of SARS-CoV-2 infection. We compared biomarkers evaluated in PASC patients with 20 healthy volunteers (HVs) and acute hospitalized COVID-19 patients (<i>n</i> = 88). The study found that angiogenesis-related biomarkers and von Willebrand factor (VWF) levels were increased in PASC patients compared to HVs without increased inflammatory or platelet activation markers. Moreover, VEGF-A and VWF were associated with persistent lung CT scan lesions and impaired diffusing capacity of the lungs for carbon monoxide (DLCO) measurement. By employing a Cox proportional hazards model adjusted for age, sex, and body mass index, we further confirmed the accuracy of VEGF-A and VWF. Following adjustment, VEGF-A emerged as the most significant predictive factor associated with persistent lung CT scan lesions and impaired DLCO measurement.</p><h3>Conclusion</h3><p>VEGF-A is a relevant predictive factor for DLCO impairment and radiological sequelae in PASC. Beyond being a biomarker, we hypothesize that the persistence of angiogenic disorders may contribute to long COVID symptoms.</p></div>\",\"PeriodicalId\":7886,\"journal\":{\"name\":\"Angiogenesis\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":9.2000,\"publicationDate\":\"2023-08-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Angiogenesis\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s10456-023-09890-9\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"PERIPHERAL VASCULAR DISEASE\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Angiogenesis","FirstCategoryId":"3","ListUrlMain":"https://link.springer.com/article/10.1007/s10456-023-09890-9","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PERIPHERAL VASCULAR DISEASE","Score":null,"Total":0}
引用次数: 0

摘要

背景:长COVID又称COVID-19急性后遗症(PASC),其特征是COVID-19后出现持续性临床症状:目的:将内皮功能障碍的生物标志物与COVID-19后的持续临床症状和肺功能缺陷相关联:方法:连续招募长期怀疑 COVID-19 的患者。在临床评估和肺功能测试(PFT)期间,对每位患者的一系列内皮生物标志物进行了测量:研究共纳入 137 名 PASC 患者,大部分为男性(68%),中位年龄为 55 岁。在感染 SARS-CoV-2 后的第 3 个月至第 24 个月期间,共进行了 194 次肺功能测试。我们将 PASC 患者与 20 名健康志愿者(HVs)和 COVID-19 急性住院患者(n = 88)的生物标志物进行了比较。研究发现,与健康志愿者相比,PASC 患者的血管生成相关生物标志物和冯-威廉因子(VWF)水平升高,但炎症或血小板活化标志物并未升高。此外,VEGF-A 和 VWF 与肺部 CT 扫描病灶持续存在和一氧化碳肺弥散能力(DLCO)测量受损有关。通过采用调整年龄、性别和体重指数的 Cox 比例危险模型,我们进一步证实了 VEGF-A 和 VWF 的准确性。经过调整,VEGF-A 成为与肺部 CT 扫描病灶持续存在和 DLCO 测量受损相关的最重要预测因素:结论:VEGF-A 是 PASC 中 DLCO 受损和放射学后遗症的相关预测因素。结论:VEGF-A 是 PASC 患者 DLCO 损伤和放射学后遗症的相关预测因素。除了作为生物标志物外,我们还假设血管生成障碍的持续存在可能会导致 COVID 症状的长期存在。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

摘要图片

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
VEGF-A plasma levels are associated with impaired DLCO and radiological sequelae in long COVID patients

Background

Long COVID, also known as post-acute sequelae of COVID-19 (PASC), is characterized by persistent clinical symptoms following COVID-19.

Objective

To correlate biomarkers of endothelial dysfunction with persistent clinical symptoms and pulmonary function defects at distance from COVID-19.

Methods

Consecutive patients with long COVID-19 suspicion were enrolled. A panel of endothelial biomarkers was measured in each patient during clinical evaluation and pulmonary function test (PFT).

Results

The study included 137 PASC patients, mostly male (68%), with a median age of 55 years. A total of 194 PFTs were performed between months 3 and 24 after an episode of SARS-CoV-2 infection. We compared biomarkers evaluated in PASC patients with 20 healthy volunteers (HVs) and acute hospitalized COVID-19 patients (n = 88). The study found that angiogenesis-related biomarkers and von Willebrand factor (VWF) levels were increased in PASC patients compared to HVs without increased inflammatory or platelet activation markers. Moreover, VEGF-A and VWF were associated with persistent lung CT scan lesions and impaired diffusing capacity of the lungs for carbon monoxide (DLCO) measurement. By employing a Cox proportional hazards model adjusted for age, sex, and body mass index, we further confirmed the accuracy of VEGF-A and VWF. Following adjustment, VEGF-A emerged as the most significant predictive factor associated with persistent lung CT scan lesions and impaired DLCO measurement.

Conclusion

VEGF-A is a relevant predictive factor for DLCO impairment and radiological sequelae in PASC. Beyond being a biomarker, we hypothesize that the persistence of angiogenic disorders may contribute to long COVID symptoms.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Angiogenesis
Angiogenesis PERIPHERAL VASCULAR DISEASE-
CiteScore
21.90
自引率
8.20%
发文量
37
审稿时长
6-12 weeks
期刊介绍: Angiogenesis, a renowned international journal, seeks to publish high-quality original articles and reviews on the cellular and molecular mechanisms governing angiogenesis in both normal and pathological conditions. By serving as a primary platform for swift communication within the field of angiogenesis research, this multidisciplinary journal showcases pioneering experimental studies utilizing molecular techniques, in vitro methods, animal models, and clinical investigations into angiogenic diseases. Furthermore, Angiogenesis sheds light on cutting-edge therapeutic strategies for promoting or inhibiting angiogenesis, while also highlighting fresh markers and techniques for disease diagnosis and prognosis.
期刊最新文献
Correction: Mitochondrial control of hypoxia-induced pathological retinal angiogenesis. Angiogenesis is limited by LIC1-mediated lysosomal trafficking. Similarities and differences between brain and skin GNAQ p.R183Q driven capillary malformations. Inflammasome activation aggravates choroidal neovascularization. Timed topical dexamethasone eye drops improve mitochondrial function to prevent severe retinopathy of prematurity
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1