细胞凋亡中的非编码 RNA:识别与功能。

Turkish journal of biology = Turk biyoloji dergisi Pub Date : 2021-11-14 eCollection Date: 2022-01-01 DOI:10.3906/biy-2109-35
Özge Tüncel, Merve Kara, Bilge Yaylak, İpek Erdoğan, Bünyamin Akgül
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摘要

细胞凋亡是一个重要的细胞过程,对于维持健康和疾病的平衡至关重要。凋亡机制的失灵会导致发育异常、癌症和神经退行性疾病等严重后果。因此,真核生物中存在着复杂的调控机制,以保持细胞生长和细胞死亡之间的平衡。最初,人们在寻找这种参与细胞凋亡调控的调控大分子时,优先考虑的是蛋白质编码基因。然而,最近的基因组注释和转录组学研究发现了大量的调控性非编码 RNA,它们不仅有能力调控细胞凋亡,还能调控真核生物的许多其他生化过程。在这篇综述文章中,我们将简要概述细胞凋亡和检测方法,然后广泛讨论细胞凋亡中的 microRNA、环状 RNA 和长非编码 RNA。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Noncoding RNAs in apoptosis: identification and function.

Apoptosis is a vital cellular process that is critical for the maintenance of homeostasis in health and disease. The derailment of apoptotic mechanisms has severe consequences such as abnormal development, cancer, and neurodegenerative diseases. Thus, there exist complex regulatory mechanisms in eukaryotes to preserve the balance between cell growth and cell death. Initially, protein-coding genes were prioritized in the search for such regulatory macromolecules involved in the regulation of apoptosis. However, recent genome annotations and transcriptomics studies have uncovered a plethora of regulatory noncoding RNAs that have the ability to modulate not only apoptosis but also many other biochemical processes in eukaryotes. In this review article, we will cover a brief summary of apoptosis and detection methods followed by an extensive discussion on microRNAs, circular RNAs, and long noncoding RNAs in apoptosis.

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