地平线扫描:英格兰牛结核病控制的下一步是什么?

IF 2.7 2区 农林科学 Q1 VETERINARY SCIENCES Irish Veterinary Journal Pub Date : 2023-07-31 DOI:10.1186/s13620-023-00242-z
James McCormack
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摘要

英格兰目前正处于实现无结核病的 25 年战略的第九年。本讲座将探讨未来可采用哪些新工具和新方法来帮助我们实现目标。我将以英国农业部对其结核病计划独立审查的回应为出发点,并以英国 CVO 的全体演讲为基础,探讨在回应的不同方面可能出现的一些机遇。首先,将考虑如何通过更明智的购买决策来帮助农民降低牛群结核病风险,包括研究最近公布的英格兰每个牛群的健康评级。牛疫苗接种及其相关的 DIVA 检测可能是英格兰结核病控制领域多年来最大的变革,而相关的分子定义结核菌素的开发可能成为默认的检测试剂。全基因组测序技术的进步将使我们能够对从英格兰大多数受感染牛群中分离出的牛结核杆菌的基因组进行测序,这些数据将为我们带来各种机会,包括追踪感染的传播情况、对检测的有效性进行地面实况调查,以及对疫情进行流行病学评估等。最后,我们将通过一个案例研究来探讨如何将疫苗接种作为控制獾结核病的主要方法,而很少使用扑杀獾的方法,该案例研究了有针对性的扑杀獾是如何成功地消除坎布里亚地区的感染并使疫苗接种成为可能的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Horizon scanning: what next for bovine TB control in England?

England is currently in year nine of its 25-year strategy to achieve TB freedom. This talk will speculate on what new tools and approaches could be introduced in the future to help us achieve our goal.Using Defra's response to the independent review of its TB programme as a starting point and building on the plenary talk by the UK CVO, I will look at some opportunities that could arise under the different aspects of the response.Firstly, how best to help farmers reduce their herd TB risk through better informed purchasing decisions will be considered, including looking at the recent publication of the health ratings for every cattle herd in England.Cattle vaccination, and its associated DIVA test could be the biggest change in Tb control in England in many years while the related development of a molecularly defined tuberculin which could become the default testing reagent.Advances in whole genome sequencing will allow us to sequence the genome of M.bovis isolated from most infected herds in England and these data could unlock a variety of opportunities from tracing the spread of infection to ground-truthing the efficacy of testing and epidemiological assessment of breakdowns.Finally, the move to vaccination as the primary way of controlling TB in badgers with culling used very sparingly will be considered using a case study of how a targeted badger cull successfully removed infection from an area in Cumbria and enabled the switch to vaccination.

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来源期刊
Irish Veterinary Journal
Irish Veterinary Journal 农林科学-兽医学
CiteScore
4.80
自引率
3.40%
发文量
1
审稿时长
>36 weeks
期刊介绍: Irish Veterinary Journal is an open access journal with a vision to make a substantial contribution to the dissemination of evidence-based knowledge that will promote optimal health and welfare of both domestic and wild species of animals. Irish Veterinary Journal has a clinical research focus with an emphasis on the effective management of health in both individual and populations of animals. Published studies will be relevant to both the international veterinary profession and veterinary scientists. Papers relating to veterinary education, veterinary ethics, veterinary public health, or relevant studies in the area of social science (participatory research) are also within the scope of Irish Veterinary Journal.
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