含盘旋卷曲结构域 3 的细胞外和细胞内功能。

IF 5.3 2区 生物学 Q2 CELL BIOLOGY Journal of Molecular Cell Biology Pub Date : 2023-11-27 DOI:10.1093/jmcb/mjad037
Sara Omari, Hyemin Lee, Jieqiong Wang, Shelya X Zeng, Hua Lu
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引用次数: 0

摘要

含有卷曲盘旋结构域的 3(CCDC3,又称 Favine)是一种高度保守的蛋白质,最初被鉴定为一种从脂肪细胞和血管系统内皮细胞分泌的蛋白质,具有类似内分泌的功能。最近,人们还发现 CCDC3 在乳腺癌中具有核肿瘤抑制因子的功能。尽管对 CCDC3 的研究还不够深入,但自发现以来,它已被证明在脂质代谢、脂肪肝、腹部肥胖、抗炎、动脉粥样硬化和癌症等方面发挥着多重作用。因此,本文将概述 CCDC3 的细胞外内分泌样功能和细胞内(核)功能。我们还讨论了 CCDC3 可能的潜在细胞和分子机制、对临床转化的影响以及有关这一特殊分子的其余谜题。
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Extracellular and intracellular functions of coiled-coil domain containing 3.

Coiled-coil domain containing 3 (CCDC3, also called Favine) is a highly conserved protein initially identified as a protein secreted from adipocytes and endothelial cells in the vascular system with endocrine-like functions. Recently, CCDC3 was also found to function as a nuclear tumor suppressor in breast cancers. Although it is still understudied, CCDC3, since its discovery, has been shown to play multiple roles in lipid metabolism, fatty liver, abdominal obesity, anti-inflammation, atherosclerosis, and cancer. This essay is thus composed to offer an overview of these extracellular endocrine-like and intracellular (nuclear) functions of CCDC3. We also discuss the possible underlying cellular and molecular mechanisms of CCDC3, the implications for clinical translation, and the remaining puzzles about this special molecule.

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来源期刊
CiteScore
9.60
自引率
1.80%
发文量
1383
期刊介绍: The Journal of Molecular Cell Biology ( JMCB ) is a full open access, peer-reviewed online journal interested in inter-disciplinary studies at the cross-sections between molecular and cell biology as well as other disciplines of life sciences. The broad scope of JMCB reflects the merging of these life science disciplines such as stem cell research, signaling, genetics, epigenetics, genomics, development, immunology, cancer biology, molecular pathogenesis, neuroscience, and systems biology. The journal will publish primary research papers with findings of unusual significance and broad scientific interest. Review articles, letters and commentary on timely issues are also welcome. JMCB features an outstanding Editorial Board, which will serve as scientific advisors to the journal and provide strategic guidance for the development of the journal. By selecting only the best papers for publication, JMCB will provide a first rate publishing forum for scientists all over the world.
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