癌症中的非编码RNA突变。

IF 6.4 2区 生物学 Q1 CELL BIOLOGY Wiley Interdisciplinary Reviews: RNA Pub Date : 2023-11-01 Epub Date: 2023-08-06 DOI:10.1002/wrna.1812
Honghong Zhou, Xinpei Hao, Peng Zhang, Shunmin He
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引用次数: 1

摘要

癌症是由生殖细胞和体细胞基因变化驱动的。人们一直致力于描述癌症发生和发展过程中的基本遗传变异。大多数的注意力都集中在蛋白质编码基因的突变和相关的调控元件,如启动子和增强子。测序技术以及计算机和实验方法的发展,使得进一步探索非编码rna(主要是长链非编码rna和microrna)的癌症易感性变异和重要体细胞突变成为可能。包括GWAS在内的关联研究揭示了lncRNA或miRNA基因和调控区域的遗传变异,包括snp和indes。这些突变改变了RNA的二级结构、表达水平和靶标识别,然后赋予携带者癌症易感性。全外显子组/基因组测序比较了癌症和正常组织,揭示了非编码RNA基因的重要体细胞突变。在各种肿瘤相关的非编码rna中已经发现了突变热点和体细胞拷贝数改变。对基因组非编码区域的研究越来越受到人们的关注和重视。癌症起源的复杂基因网络正在被揭开。本文分类如下:RNA在疾病和发展> RNA在疾病。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Noncoding RNA mutations in cancer.

Cancer is driven by both germline and somatic genetic changes. Efforts have been devoted to characterizing essential genetic variations in cancer initiation and development. Most attention has been given to mutations in protein-coding genes and associated regulatory elements such as promoters and enhancers. The development of sequencing technologies and in silico and experimental methods has allowed further exploration of cancer predisposition variants and important somatic mutations in noncoding RNAs, mainly for long noncoding RNAs and microRNAs. Association studies including GWAS have revealed hereditary variations including SNPs and indels in lncRNA or miRNA genes and regulatory regions. These mutations altered RNA secondary structures, expression levels, and target recognition and then conferred cancer predisposition to carriers. Whole-exome/genome sequencing comparing cancer and normal tissues has revealed important somatic mutations in noncoding RNA genes. Mutation hotspots and somatic copy number alterations have been identified in various tumor-associated noncoding RNAs. Increasing focus and effort have been devoted to studying the noncoding region of the genome. The complex genetic network of cancer initiation is being unveiled. This article is categorized under: RNA in Disease and Development > RNA in Disease.

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来源期刊
CiteScore
14.80
自引率
4.10%
发文量
67
审稿时长
6-12 weeks
期刊介绍: WIREs RNA aims to provide comprehensive, up-to-date, and coherent coverage of this interesting and growing field, providing a framework for both RNA experts and interdisciplinary researchers to not only gain perspective in areas of RNA biology, but to generate new insights and applications as well. Major topics to be covered are: RNA Structure and Dynamics; RNA Evolution and Genomics; RNA-Based Catalysis; RNA Interactions with Proteins and Other Molecules; Translation; RNA Processing; RNA Export/Localization; RNA Turnover and Surveillance; Regulatory RNAs/RNAi/Riboswitches; RNA in Disease and Development; and RNA Methods.
期刊最新文献
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