一种用于动脉粥样硬化成像的脂质激活荧光探针

IF 3.4 3区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Chemistry and Physics of Lipids Pub Date : 2023-07-01 DOI:10.1016/j.chemphyslip.2022.105272

Bing Han , Ming Bai , Jin Zhang , Xiaoxue Meng , Zheng Zhang

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引用次数: 0

摘要

脂质被认为是动脉粥样硬化诊断的一个有希望的目标。然而，目前临床上还没有可用的脂质成像技术。在此，我们制备了一种荧光探针TPN用于动脉粥样硬化的脂质特异性成像。TPN在水中的发射极弱，而在脂质环境下的发射在666 nm处显著增强。同时，TPN具有较低的细胞毒性和高信噪比的细胞内脂质特异性荧光成像能力。重要的是，TPN可以特异性染色动脉粥样硬化斑块中的脂质，这将是动脉粥样硬化诊断的潜在候选者。

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A lipid activatable fluorescence probe for atherosclerosis imaging

Lipid has been considered as a promising target for atherosclerosis diagnosis. However, there is still no available lipid imaging technology in clinic. Herein, we have prepared a fluorescence probe TPN for lipid-specific imaging in atherosclerosis. TPN exhibited extremely weak emission in water, while its emission was significantly enhanced in lipid environment at 666 nm. Meanwhile, TPN has showed low cytotoxicity and great intracellular lipid-specific fluorescence imaging ability with high signal-to-noise ratio. Importantly, TPN could specifically stain the lipid in atherosclerotic plaque, which would be a potential candidate for the diagnosis of atherosclerosis.

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来源期刊

Chemistry and Physics of Lipids 生物-生化与分子生物学

CiteScore

7.60

自引率

2.90%

发文量

审稿时长

40 days

期刊介绍： Chemistry and Physics of Lipids publishes research papers and review articles on chemical and physical aspects of lipids with primary emphasis on the relationship of these properties to biological functions and to biomedical applications. Accordingly, the journal covers: advances in synthetic and analytical lipid methodology; mass-spectrometry of lipids; chemical and physical characterisation of isolated structures; thermodynamics, phase behaviour, topology and dynamics of lipid assemblies; physicochemical studies into lipid-lipid and lipid-protein interactions in lipoproteins and in natural and model membranes; movement of lipids within, across and between membranes; intracellular lipid transfer; structure-function relationships and the nature of lipid-derived second messengers; chemical, physical and functional alterations of lipids induced by free radicals; enzymatic and non-enzymatic mechanisms of lipid peroxidation in cells, tissues, biofluids; oxidative lipidomics; and the role of lipids in the regulation of membrane-dependent biological processes.