天然药物的工业全合成。

IF 10.2 1区化学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Natural Product Reports Pub Date : 2023-11-15 DOI:10.1039/d3np00020f

Xiao-Yu Liu , Yong Qin

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引用次数: 0

摘要

如果由于天然丰度低或缺乏有效的发酵或半合成方法而无法获得足够数量的天然药物，则全合成提供了生产天然药物的关键方法。本观点概述了过去和目前的研究状况，因为它们适用于工业规模的天然药物全合成，并提供了该领域未来发展潜力的整体观点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Industrial total synthesis of natural medicines

Total synthesis offers a key approach to the production of natural medicines if sufficient quantities cannot be obtained due to low natural abundance or lack of efficient fermentation or semi-synthesis methods. This Viewpoint outlines the previous and current states of research as they apply to the total synthesis of natural medicines on an industrial scale and provides a holistic view on the potential for future developments in the field.

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来源期刊

Natural Product Reports 化学-生化与分子生物学

CiteScore

21.20

自引率

3.40%

发文量

127

审稿时长

1.7 months

期刊介绍： Natural Product Reports (NPR) serves as a pivotal critical review journal propelling advancements in all facets of natural products research, encompassing isolation, structural and stereochemical determination, biosynthesis, biological activity, and synthesis. With a broad scope, NPR extends its influence into the wider bioinorganic, bioorganic, and chemical biology communities. Covering areas such as enzymology, nucleic acids, genetics, chemical ecology, carbohydrates, primary and secondary metabolism, and analytical techniques, the journal provides insightful articles focusing on key developments shaping the field, rather than offering exhaustive overviews of all results. NPR encourages authors to infuse their perspectives on developments, trends, and future directions, fostering a dynamic exchange of ideas within the natural products research community.