居住在社区的老年妇女中110kDa C-末端农业蛋白片段与骨骼肌衰退之间的关系。

IF 8.9 1区 医学 Journal of Cachexia, Sarcopenia and Muscle Pub Date : 2023-08-10 DOI:10.1002/jcsm.13309
Kuniyasu Kamiya, Takahiro Tachiki, Yuho Sato, Katsuyasu Kouda, Etsuko Kajita, Junko Tamaki, Sadanobu Kagamimori, Masayuki Iki
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引用次数: 0

摘要

背景:C-末端农业蛋白片段(CAF)是神经肌肉接头降解的生物标志物。本研究旨在调查110kDa CAF(CAF110)是否与低肌肉质量和力量的存在和发生率有关。方法:这项横断面回顾性队列研究包括年龄≥65岁的女性。2011年至2012年间,我们使用双能X射线吸收仪扫描仪、握力和血液采样测量了肌肉质量。2015年至2017年间进行了一项具有相同测量值的后续研究。低肌肉质量和力量被定义为阑尾骨骼肌质量指数2和握力。结果:共有515名女性(74.3±6.3岁)被纳入该横断面分析。其中,101名(19.6%)和128名(24.9%)女性的肌肉质量和力量分别较低。对于低肌肉质量,与最低组相比,中等和最高CAF110三分位数组的比值比(OR)分别为1.93(95%置信区间:1.09-3.43;P=0.024)和2.15(1.22-3.80;P=0.008)。校正年龄后,ORs仍然显著:分别为1.98(1.11-3.52;P=0.020)和2.27(1.28-4.03;P=0.005)。所有CAF110三分位组的低肌力ORs均不显著。在纵向分析中,分别对292名和289名女性的肌肉质量和力量低下事件进行了评估。其中,34名(11.6%)和20名(6.9%)女性的肌肉质量和力量分别较低。对于发生的低肌肉质量,CAF110≥中值组的粗OR略高于CAF110。结论:CAF110与低肌肉强度无关。然而,CAF110可能是低肌肉质量发生率的潜在标志物。
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Association between the 110-kDa C-terminal agrin fragment and skeletal muscle decline among community-dwelling older women

Background

C-terminal agrin fragment (CAF) is a biomarker for neuromuscular junction degradation. This study aimed to investigate whether 110-kDa CAF (CAF110) was associated with the presence and incidence of low muscle mass and strength.

Methods

This cross-sectional retrospective cohort study comprised women aged ≥65 years. We measured muscle mass using a dual-energy X-ray absorptiometry scanner, hand-grip strength, and blood sampling between 2011 and 2012. A follow-up study with the same measurements was conducted between 2015 and 2017. Low muscle mass and strength were defined as an appendicular skeletal muscle mass index <5.4 kg/m2 and hand-grip strength <18 kg, respectively. The CAF110 level was measured using enzyme-linked immunosorbent assay kits.

Results

In total, 515 women (74.3 ± 6.3 years) were included in this cross-sectional analysis. Of these, 101 (19.6%) and 128 (24.9%) women presented with low muscle mass and strength, respectively. For low muscle mass, the odds ratios (ORs) of the middle and highest CAF110 tertile groups, compared with the lowest group, were 1.93 (95% confidence interval: 1.09–3.43; P = 0.024) and 2.15 (1.22–3.80; P = 0.008), respectively. After adjusting for age, the ORs remained significant: 1.98 (1.11–3.52; P = 0.020) and 2.27 (1.28–4.03; P = 0.005), respectively. Low muscle strength ORs of all the CAF110 tertile groups were not significant. In the longitudinal analysis, 292 and 289 women were assessed for incidents of low muscle mass and strength, respectively. Of those, 34 (11.6%) and 20 (6.9%) women exhibited low muscle mass and strength, respectively. For incident low muscle mass, the crude OR of the CAF110 ≥ the median value group was marginally higher than that of the CAF110 < median value group (median [interquartile range]: 1.98 [0.94–4.17] (P = 0.072). After adjusting for age and baseline muscle mass, the OR was 2.22 [0.97–5.06] (P = 0.058). All low muscle strength ORs of the median categories of CAF110 were not significant.

Conclusions

CAF110 was not associated with low muscle strength. However, CAF110 may be a potential marker for the incidence of low muscle mass.

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来源期刊
Journal of Cachexia, Sarcopenia and Muscle
Journal of Cachexia, Sarcopenia and Muscle Medicine-Orthopedics and Sports Medicine
自引率
12.40%
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0
期刊介绍: The Journal of Cachexia, Sarcopenia, and Muscle is a prestigious, peer-reviewed international publication committed to disseminating research and clinical insights pertaining to cachexia, sarcopenia, body composition, and the physiological and pathophysiological alterations occurring throughout the lifespan and in various illnesses across the spectrum of life sciences. This journal serves as a valuable resource for physicians, biochemists, biologists, dieticians, pharmacologists, and students alike.
期刊最新文献
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