结合刺突蛋白的cervis ACE2残基可提供对SARS-CoV-2的易感性

IF 2.2 3区环境科学与生态学 Q3 ENVIRONMENTAL SCIENCES Ecohealth Pub Date : 2023-03-01 DOI:10.1007/s10393-023-01632-z

Luciano Rodrigo Lopes

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引用次数: 1

摘要

白尾鹿(WTD)的易感性;严重急性呼吸系统综合征冠状病毒2型(SARS-CoV-2)的发现突出了猪是冠状病毒的宿主。本研究旨在评价16种冠状病毒刺突蛋白结合的血管紧张素转换酶2 (ACE2)残基，以预测其对SARS-CoV-2感染的潜在易感性。16种中有11种的ACE2关键残基与WTD ACE2相同。4名患者出现K31N，这是一种与低SARS-CoV-2易感性相关的变异。具有与WTD相同的ACE2关键残基的大量种群可能导致SARS-CoV-2的广泛储存库。猪作为潜在的宿主可能有利于SARS-CoV-2的适应和新的冠状病毒株的出现。

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Cervids ACE2 Residues that Bind the Spike Protein can Provide Susceptibility to SARS-CoV-2.

The susceptibility of the white-tailed deer (WTD; Odocoileus virginianus) to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has highlighted cervids as coronavirus reservoirs. This study aimed to evaluate the angiotensin-converting enzyme 2 (ACE2) residues which bind the spike protein of SARS-CoV-2 from 16 cervids to predict their potential susceptibility to SARS-CoV-2 infection. Eleven out of 16 species presented identical ACE2 key residues to WTD ACE2. Four cervids presented K31N, a variant associated with low SARS-CoV-2 susceptibility. Large herding of cervids with ACE2 key residues identical to that of the WTD can result in extensive reservoirs of SARS-CoV-2. Cervids as potential reservoirs could favor SARS-CoV-2 adaptation and the emergence of new coronavirus strains.

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来源期刊

Ecohealth 环境科学-环境科学

CiteScore

4.50

自引率

4.00%

发文量

审稿时长

>24 weeks

期刊介绍： EcoHealth aims to advance research, practice, and knowledge integration at the interface of ecology and health by publishing high quality research and review articles that address and profile new ideas, developments, and programs. The journal’s scope encompasses research that integrates concepts and theory from many fields of scholarship (including ecological, social and health sciences, and the humanities) and draws upon multiple types of knowledge, including those of relevance to practice and policy. Papers address integrated ecology and health challenges arising in public health, human and veterinary medicine, conservation and ecosystem management, rural and urban development and planning, and other fields that address the social-ecological context of health. The journal is a central platform for fulfilling the mission of the EcoHealth Alliance to strive for sustainable health of people, domestic animals, wildlife, and ecosystems by promoting discovery, understanding, and transdisciplinarity. The journal invites substantial contributions in the following areas: One Health and Conservation Medicine o Integrated research on health of humans, wildlife, livestock and ecosystems o Research and policy in ecology, public health, and agricultural sustainability o Emerging infectious diseases affecting people, wildlife, domestic animals, and plants o Research and practice linking human and animal health and/or social-ecological systems o Anthropogenic environmental change and drivers of disease emergence in humans, wildlife, livestock and ecosystems o Health of humans and animals in relation to terrestrial, freshwater, and marine ecosystems Ecosystem Approaches to Health o Systems thinking and social-ecological systems in relation to health o Transdiiplinary approaches to health, ecosystems and society.