合成类维生素a超越癌症治疗。

IF 11.2 1区 医学 Q1 PHARMACOLOGY & PHARMACY Annual review of pharmacology and toxicology Pub Date : 2022-01-06 DOI:10.1146/annurev-pharmtox-052120-104428
Lorraine J Gudas
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引用次数: 7

摘要

虽然类维甲酸在癌症治疗中的应用不断发展,但本综述侧重于类维甲酸[视黄醇(维生素A),全反式维甲酸(RA)和合成维甲酸受体(RAR)α-, β-和γ-选择性激动剂]正在使用的其他治疗领域,以及有希望的新研究,这些研究表明类维甲酸可用于治疗肾脏,骨骼肌,心脏,胰腺,肝脏,神经系统,皮肤和其他器官的疾病。就美国食品和药物管理局批准的rar选择性激动剂而言,最成熟的领域是用于治疗各种皮肤病。合成类维甲酸激动剂比内源性RAR激动剂(如RA)具有主要优势。因为它们通过特定的RAR起作用,副作用可能会最小化,而且合成类维生素a通常比RA具有更好的药物特性。基于我们对类维生素a在发育、表观遗传调控和组织修复中的多重作用的不断增加的认识,其他令人兴奋的治疗领域正在出现。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Synthetic Retinoids Beyond Cancer Therapy.

While the uses of retinoids for cancer treatment continue to evolve, this review focuses on other therapeutic areas in which retinoids [retinol (vitamin A), all-trans retinoic acid (RA), and synthetic retinoic acid receptor (RAR)α-, β-, and γ-selective agonists] are being used and on promising new research that suggests additional uses for retinoids for the treatment of disorders of the kidneys, skeletal muscles, heart, pancreas, liver, nervous system, skin, and other organs. The most mature area, in terms of US Food and Drug Administration-approved, RAR-selective agonists, is for treatment of various skin diseases. Synthetic retinoid agonists have major advantages over endogenous RAR agonists such as RA. Because they act through a specific RAR, side effects may be minimized, and synthetic retinoids often have better pharmaceutical properties than does RA. Based on our increasing knowledge of the multiple roles of retinoids in development, epigenetic regulation, and tissue repair, other exciting therapeutic areas are emerging.

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来源期刊
CiteScore
27.80
自引率
0.00%
发文量
53
期刊介绍: Since 1961, the Annual Review of Pharmacology and Toxicology has been a comprehensive resource covering significant developments in pharmacology and toxicology. The journal encompasses various aspects, including receptors, transporters, enzymes, chemical agents, drug development science, and systems like the immune, nervous, gastrointestinal, cardiovascular, endocrine, and pulmonary systems. Special topics are also featured in this annual review.
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