Frontiers in Chemical Biology

In silico enzyme screening identifies an SDR ketoreductase from Thermus caliditerrae as an attractive biocatalyst and promising candidate for protein engineering

Pub Date : 2024-07-23 DOI: 10.3389/fchbi.2024.1425501 Yvett Sosa, Bhav Kapur, Jessica Hurtak, Laura J. Kingsley, Hao Wu, Stefanie Gruber, Herbert Nar, Saad Khattabi, Jesus Seco Moral, Maria Fátima Lucas, Caterina Martin, Nikola Lončar, Frederic Buono, Noah Pefaur, Andrew E. Nixon, Jinhua J. Song

Generation and preclinical evaluation of a human heavy-chain-only antibody recognizing the membrane-bound tumor-associated antigen mesothelin

Pub Date : 2024-07-22 DOI: 10.3389/fchbi.2024.1408621 R. Janssens, R. van Haperen, Michael van der Reijden, Alex Maas, Jingsong Wang, Frank Grosveld, D. Drabek

The chemistry of Formycin biosynthesis

Pub Date : 2024-07-12 DOI: 10.3389/fchbi.2024.1428646 Nigel G. J. Richards, James H. Naismith