Maintenance of Immune Balance: Effects of Targeted and Immune Therapies

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Abstract A134: Single-cell roadmap of the evolution of T-cell response during anti-LAG3 and anti-PD1 combination treatment in metastatic melanoma patients

Pub Date : 2019-02-01 DOI: 10.1158/2326-6074.CRICIMTEATIAACR18-A134 J. Huuhtanen, Henna Hakanen, T. Lönnberg, O. Dufva, K. Peltola, S. Mäkelä, M. Hernberg, P. Bono, K. Anna, S. Mustjoki

Abstract A146: Systematic discovery of immune regulatory mechanisms in tumor cells

Pub Date : 2019-02-01 DOI: 10.1158/2326-6074.CRICIMTEATIAACR18-A146 D. Pan, A. Kobayashi, Peng Jiang, Guocheng Yuan, X. Liu, John G Doench, Xintao Qiu, P. Rao, Henry W. Long, Myles A. Brown, K. Wucherpfennig, L. F. Andrade, Rong En Tay, Adrienne M. Luoma, Daphne M Tsoucas, Klothilda Lim

Abstract A125: Pulsatile MEK inhibition improves antitumor immunity and T-cell function in Kras mutant lung cancer

Pub Date : 2019-02-01 DOI: 10.1158/2326-6074.CRICIMTEATIAACR18-A125 Hyejin Choi, Jiehui Deng, Shuai Li, Tarik Silk, E. Brea, Jonathan A Boiarsky, E. Akbay, Paul D. Smith, T. Merghoub, Kwok-kin Wong, J. Wolchok

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