Research Square

Viral genome sequence datasets display pervasive evidence of strand-specific substitution biases that are best described using non-reversible nucleotide substitution models.

Pub Date : 2025-08-08 DOI: 10.21203/rs.3.rs-2407778/v2 Rita Sianga-Mete, Penelope Hartnady, Wimbai Caroline Mandikumba, Kayleigh Rutherford, Christopher Brian Currin, Florence Phelanyane, Sabina Stefan, Steven Weaver, Sergei L Kosakovsky Pond, Darren P Martin

Structure of METTL3-METTL14 with an m6A nucleotide reveals insights into m6A conversion and sensing.

Pub Date : 2024-10-23 DOI: 10.21203/rs.3.rs-3150186/v2 Shan Qi, Abhay Kumar, Shuang Chen, Shuo Zhou, Manish Parihar, Carmen Villalobos, Navom Gupta, Siu-Hong Chan, Manjeet K Rao, Stanton F McHardy, Shozeb Haider, Yogesh K Gupta

Combination of a MIP3α-antigen fusion therapeutic DNA vaccine with treatments of IFNα and 5-Aza-2'Deoxycytidine enhances activated effector CD8+ T cells expressing CD11c in the B16F10 melanoma model.

Pub Date : 2024-08-20 DOI: 10.21203/rs.3.rs-3243336/v2 Kaitlyn Fessler, Jiaqi Zhang, Avinaash K Sandhu, Yinan Hui, Aakanksha R Kapoor, Samuel K Ayeh, Styliani Karanika, Petros C Karakousis, Richard B Markham, James T Gordy