J: Clinical therapeutics

J06 Pivot-HD: a phase 2, randomised, placebo-controlled study to evaluate the safety and efficacy of ptc518 in subjects with Huntington’s disease

Pub Date : 2022-09-01 DOI: 10.1136/jnnp-2022-ehdn.256 B. Beers, A. Bredlau, Anusuya Bhattacharyya, A. Kristensen, L. Golden, M. Klein, S. Peltz

J11 Pridopidine exerts beneficial effects in preclinical models and in clinical trials via activation of the sigma-1 receptor, in a biphasic manner

Pub Date : 2022-09-01 DOI: 10.1136/jnnp-2022-ehdn.261 M. Geva, Deniz Akinc Abdulhayoglu, Shao-Ming Wang, Noga Gershoni-Emek, B. Boulanger, Y. P. Goldberg, T. Su, M. R. Hayden

J02 Quantitative analyses of pooled tominersen clinical data to support dose selection (rationale) for the new phase II study

Pub Date : 2022-09-01 DOI: 10.1136/jnnp-2022-ehdn.252 Yumi Yamamoto, Julian Zhou, P. Grimsey, P. McColgan, P. Ducray