Biophysical and Computational Tools in Drug Discovery

Probing with Pharmacophore Modeling the Chloroquine Resistance and Designing Novel Antimalarials

Pub Date : 1900-01-01 DOI: 10.1007/7355_2021_131 Pawan Kumar, I. Ghosh

Kinetic Profiling of Ligands and Fragments Binding to GPCRs by TR-FRET

Pub Date : 1900-01-01 DOI: 10.1007/7355_2021_120 D. Sykes, Leire Borrega-Román, Clare R. Harwood, Bradley L. Hoare, Jack M. Lochray, Thais Gazzi, S. Briddon, M. Nazaré, U. Grether, S. Hill, S. Charlton, D. Veprintsev

A Rapid Computational Screening of Millions of Molecules to Identify Sequence-Specific DNA Minor Groove Binders via Physicochemical Descriptors

Pub Date : 1900-01-01 DOI: 10.1007/7355_2021_122 Pradeep Pant, B. Jayaram