The EMBO Journal

SLC13A2 promotes hepatocyte metabolic remodeling and liver regeneration by enhancing de novo cholesterol biosynthesis.

Pub Date : 2025-01-17 DOI: 10.1038/s44318-025-00362-y Li Shi,Hao Chen,Yuxin Zhang,Donghao An,Mengyao Qin,Wanting Yu,Bin Wen,Dandan He,Haiping Hao,Jing Xiong

The microcephaly-associated transcriptional regulator AUTS2 cooperates with Polycomb complex PRC2 to produce upper-layer neurons in mice.

Pub Date : 2025-01-15 DOI: 10.1038/s44318-024-00343-7 Kazumi Shimaoka,Kei Hori,Satoshi Miyashita,Yukiko U Inoue,Nao K N Tabe,Asami Sakamoto,Ikuko Hasegawa,Kayo Nishitani,Kunihiko Yamashiro,Saki F Egusa,Shoji Tatsumoto,Yasuhiro Go,Manabu Abe,Kenji Sakimura,Takayoshi Inoue,Takuya Imamura,Mikio Hoshino

Recruitment of autophagy initiator TAX1BP1 advances aggrephagy from cargo collection to sequestration.

Pub Date : 2024-10-24 DOI: 10.1038/s44318-024-00280-5 Bernd Bauer,Jonas Idinger,Martina Schuschnig,Luca Ferrari,Sascha Martens