Therapeutic targets for neurological diseases

SRSF1-dependent nuclear export of C9ORF72 repeat transcripts: targeting toxic gain-of-functions induced by protein sequestration as a selective therapeutic strategy for neuroprotection

Pub Date : 2018-01-15 DOI: 10.14800/TTND.1619 L. Castelli, Ya-Hui Lin, L. Ferraiuolo, Alvaro Sanchez-Martinez, K. Ning, M. Azzouz, Alexander J. Whitworth, P. Shaw, Guillaume M. Hautbergue

Insights into abnormal sphingolipid metabolism in multiple sclerosis: targeting ceramide biosynthesis as a unique therapeutic strategy

Pub Date : 2017-10-02 DOI: 10.14800/TTND.1598 S. Dasgupta, S. Ray

The synthesis of polyhydroxy sterone 2β,3α,5-trihydroxy-5α-androst-6-one and its neuroprotection

Pub Date : 2017-06-19 DOI: 10.14800/TTND.1559 Minyu Xie, Xinhua Li, Li-qiang Yuan, Yiyu Chen, Xiaolei Zhang, Wei Yin, Bing-zheng Lu, Zhu Zhu, Haitao Shi, Jingxia Zhang