Cell metabolism

Serine and glycine physiology reversibly modulate retinal and peripheral nerve function.

Pub Date : 2024-10-01 DOI: 10.1016/j.cmet.2024.07.021 Esther W Lim, Regis J Fallon, Caleb Bates, Yoichiro Ideguchi, Takayuki Nagasaki, Michal K Handzlik, Emeline Joulia, Roberto Bonelli, Courtney R Green, Brendan R E Ansell, Maki Kitano, Ilham Polis, Amanda J Roberts, Shigeki Furuya, Rando Allikmets, Martina Wallace, Martin Friedlander, Christian M Metallo, Marin L Gantner

Obesity intensifies sex-specific interferon signaling to selectively worsen central nervous system autoimmunity in females.

Pub Date : 2024-10-01 DOI: 10.1016/j.cmet.2024.07.017 Brendan Cordeiro, Jeeyoon Jennifer Ahn, Saurabh Gawde, Carmen Ucciferri, Nuria Alvarez-Sanchez, Xavier S Revelo, Natalie Stickle, Kaylea Massey, David G Brooks, Joel M Guthridge, Gabriel Pardo, Daniel A Winer, Robert C Axtell, Shannon E Dunn

Cytosolic calcium regulates hepatic mitochondrial oxidation, intrahepatic lipolysis, and gluconeogenesis via CAMKII activation.

Pub Date : 2024-10-01 DOI: 10.1016/j.cmet.2024.07.016 Traci E LaMoia, Brandon T Hubbard, Mateus T Guerra, Ali Nasiri, Ikki Sakuma, Mario Kahn, Dongyan Zhang, Russell P Goodman, Michael H Nathanson, Yasemin Sancak, Mark Perelis, Vamsi K Mootha, Gerald I Shulman