Chemical biology & drug design

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Structure-Based Design of 2-Aminopyrazolpyrimidopyridone Derivatives as New Rearranged During Transfection (RET) Kinase Inhibitors.

Pub Date : 2025-01-01 DOI: 10.1111/cbdd.70039 Jiayi Shen, Jihu Liu, Zhiyong Tan, Anzhi Li, Sheng Chen, Yongdong Li

Evaluation of Larger Side-Group Functionalities and the Side/End-Group Interplay in Ritonavir-Like Inhibitors of CYP3A4.

Pub Date : 2025-01-01 DOI: 10.1111/cbdd.70043 Eric R Samuels, Irina F Sevrioukova

Hepatocellular Carcinoma Cells in Humans Exhibit Resistance to Suberoylanilide Hydroxamic Acid (SAHA) Owing to the Diminished Level of Hsa-miR-125a-5p.

Pub Date : 2025-01-01 DOI: 10.1111/cbdd.70040 Shih-Wen Kao, Wei-Wen Kuo, Bruce Chi-Kang Tsai, Ebro Chawesa Mwakalinga, Thomas Gabriel Mhone, Ming-Cheng Chen, Chia-Hua Kuo, Yi-Sheng Liu, Shinn-Zong Lin, Chih-Yang Huang

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