Impact of Increased Activated Protein-C Resistance, Decreased Antithrombin III Activity and Hypocomplementemia on the Gestational Outcomes of Pregnancies with MTHFR Polymorphisms.

IF 0.7 4区医学 Q4 OBSTETRICS & GYNECOLOGY Zeitschrift fur Geburtshilfe und Neonatologie Pub Date : 2023-12-01 Epub Date: 2023-08-14 DOI:10.1055/a-2134-6452

Erdem Fadiloglu, Hanife Guler Donmez, Kemal Beksac, Mehmet Sinan Beksac

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Abstract

Objective: To evaluate the impact of increased Activated Protein C (APC) resistance, decreased antithrombin III activity and hypocomplementemia on the pregnancy outcomes of the patients with methylentetrahydrofolate reductase (MTHFR) polymorphisms.

Methods: This study was composed of 83 pregnancies with MTHFR polymorphisms. Increased APC resistance, decreased antithrombin III activity and hypocomplementemia were accepted as risk factors for poor gestational outcome.

Results: Having at least one risk factor resulted in significantly higher rates of "APGAR score of<7" at the first ten minutes (p=0.009). Composite adverse outcome rate was also higher in patients with at least one of the defined risk factors despite lack of statistical significance (p=0.241). Rate of newborn with an "APGAR score of<7" at first ten minutes was significantly higher at patients with hypocomplementemia (p=0.03).

Conclusion: Hypocomplementemia is a risk factor for poor gestational outcome in pregnancies with MTHFR polymorphisms.

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活化蛋白c抵抗增加、抗凝血酶III活性降低和补血不足对MTHFR多态性妊娠结局的影响

目的:探讨活化蛋白C (Activated Protein C, APC)抗性升高、抗凝血酶III活性降低和低补体血症对亚甲基四氢叶酸还原酶(MTHFR)多态性患者妊娠结局的影响。方法:本研究由83例MTHFR多态性孕妇组成。APC耐药增加，抗凝血酶III活性降低和补血不足被认为是妊娠结局不良的危险因素。结果:至少有一个危险因素导致APGAR评分显著升高。结论:低补体血症是MTHFR多态性妊娠不良结局的一个危险因素。

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