p53 expression is associated with tumor stage, grade and subtype in patients with hepatocellular carcinoma.

IF 1.4 Q4 ONCOLOGY Molecular and clinical oncology Pub Date : 2023-07-01 DOI:10.3892/mco.2023.2650
Nur Rahadiani, Marini Stephanie, Alif Gilang Perkasa, Diah Rini Handjari, Ening Krisnuhoni
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Abstract

The present study aimed to determine the expression levels of p53 in patients with hepatocellular carcinoma (HCC) and to evaluate its association with several HCC-related prognostic factors and in particular, with tumor stage, grade and subtype. Therefore, a cross-sectional study, involving 41 patients with HCC, who underwent surgical resection between January, 2013 and December, 2020 was conducted. To assess the expression levels of p53 in all patients with HCC, immunohistochemical staining was performed. In addition, the association between p53 expression and the clinicopathological characteristics of patients with HCC, including prognostic factors, was evaluated by applying the appropriate statistical analysis methods. The results revealed that among the 41 patients enrolled, 35 patients (85.4%) were positive for p53 expression. A higher percentage of positive p53 expression was observed in male patients >60 years old, with single HCC nodules >5 cm in diameter and vascular invasion, compared with their counterparts. A positive p53 expression was associated with well- and poorly differentiated HCC, but not with tumor stage and subtype. No differences in p53 expression were observed across different tumor stages and subtypes. Additionally, patients with moderately and poorly differentiated HCC exhibited significantly higher p53 expression levels compared with those suffering from well-differentiated HCC. Overall, the results demonstrated that the rate of p53 immuno-positive cells was increased in patients with HCC. In addition, p53 expression was associated with well- and poorly differentiated HCC, thus suggesting its association with a poorer prognosis.

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肝癌患者中P53的表达与肿瘤分期、分级和亚型相关。
本研究旨在确定p53在肝细胞癌(HCC)患者中的表达水平,并评估其与几种HCC相关预后因素的关系,特别是与肿瘤分期、分级和亚型的关系。因此,我们对2013年1月至2020年12月接受手术切除的41例HCC患者进行了横断面研究。为了评估p53在所有HCC患者中的表达水平,我们进行了免疫组织化学染色。此外,通过适当的统计分析方法,评估p53表达与HCC患者临床病理特征(包括预后因素)之间的关系。结果显示,入组的41例患者中,35例(85.4%)患者p53表达阳性。>60岁、单发肝癌结节直径> 5cm且有血管浸润的男性患者中p53阳性表达比例较高。p53阳性表达与分化良好和低分化的HCC相关,但与肿瘤分期和亚型无关。不同肿瘤分期和亚型间p53表达无差异。此外,中分化和低分化HCC患者的p53表达水平明显高于高分化HCC患者。总的来说,结果表明p53免疫阳性细胞的比例在HCC患者中增加。此外,p53表达与分化良好和低分化的HCC相关,提示其与较差的预后相关。
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CiteScore
2.80
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0.00%
发文量
108
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