Fusobacterium nucleatum: a novel immune modulator in breast cancer?

IF 4.5 2区 医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Expert Reviews in Molecular Medicine Pub Date : 2023-04-03 DOI:10.1017/erm.2023.9
Alexa Little, Mark Tangney, Michael M Tunney, Niamh E Buckley
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引用次数: 3

Abstract

Breast cancer was the most commonly diagnosed cancer worldwide in 2020. Greater understanding of the factors which promote tumour progression, metastatic development and therapeutic resistance is needed. In recent years, a distinct microbiome has been detected in the breast, a site previously thought to be sterile. Here, we review the clinical and molecular relevance of the oral anaerobic bacterium Fusobacterium nucleatum in breast cancer. F. nucleatum is enriched in breast tumour tissue compared with matched healthy tissue and has been shown to promote mammary tumour growth and metastatic progression in mouse models. Current literature suggests that F. nucleatum modulates immune escape and inflammation within the tissue microenvironment, two well-defined hallmarks of cancer. Furthermore, the microbiome, and F. nucleatum specifically, has been shown to affect patient response to therapy including immune checkpoint inhibitors. These findings highlight areas of future research needed to better understand the influence of F. nucleatum in the development and treatment of breast cancer.

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核梭杆菌:乳腺癌中一种新的免疫调节剂?
2020年,乳腺癌是全球最常见的癌症。需要更好地了解促进肿瘤进展、转移发展和治疗耐药的因素。近年来,在乳房中发现了一种独特的微生物群,而乳房以前被认为是无菌的。在这里,我们回顾口腔厌氧杆菌核梭杆菌在乳腺癌中的临床和分子相关性。与匹配的健康组织相比,核核梭菌在乳腺肿瘤组织中富集,并在小鼠模型中显示可促进乳腺肿瘤生长和转移进展。目前的文献表明,核梭菌调节免疫逃逸和组织微环境中的炎症,这是癌症的两个明确的标志。此外,微生物组,特别是具核梭菌,已被证明会影响患者对包括免疫检查点抑制剂在内的治疗的反应。这些发现突出了未来的研究领域,需要更好地了解具核梭菌在乳腺癌发展和治疗中的影响。
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来源期刊
Expert Reviews in Molecular Medicine
Expert Reviews in Molecular Medicine BIOCHEMISTRY & MOLECULAR BIOLOGY-MEDICINE, RESEARCH & EXPERIMENTAL
CiteScore
7.40
自引率
1.60%
发文量
45
期刊介绍: Expert Reviews in Molecular Medicine is an innovative online journal featuring authoritative and timely Reviews covering gene therapy, immunotherapeutics, drug design, vaccines, genetic testing, pathogenesis, microbiology, genomics, molecular epidemiology and diagnostic techniques. We especially welcome reviews on translational aspects of molecular medicine, particularly those related to the application of new understanding of the molecular basis of disease to experimental medicine and clinical practice.
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