A systematic review and meta-analysis of the omega-3 fatty acids effects on brain-derived neurotrophic factor (BDNF).

IF 3.6 4区医学 Q2 NEUROSCIENCES Nutritional Neuroscience Pub Date : 2024-07-01 Epub Date: 2023-08-17 DOI:10.1080/1028415X.2023.2245996

Somayeh Ziaei, Shooka Mohammadi, Motahareh Hasani, Mehrnaz Morvaridi, Andrej Belančić, Elnaz Daneshzad, Saleh A K Saleh, Heba M Adly, Javad Heshmati

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Abstract

Background: Omega-3 fatty acids (omega-3 FAs) have attracted the attention of researchers because of their influence on circulatory levels of brain-derived neurotrophic factor (BDNF). Our objective was to review systematically and Meta-analyze randomized controlled trials (RCTs) to assess the effects of omega-3 FAs supplementation on serum BDNF concentration.

Methods: Scopus, PubMed, Web of Science, and Cochrane Library were systematically searched until April 2023. The Cochrane risk of bias assessment tool was utilized to evaluate the quality of the studies. A random-effects model was employed to estimate the overall effect size of BDNF levels, using the Standard Mean Difference (SMD) and a 95% confidence interval (CI). The heterogeneity among the studies was assessed using chi-squared and I2 statistics.

Results: A total of 12 studies involving 587 subjects were included. The supplementation of PUFA was found to be associated with a significant increase in serum levels of BNDF in the group receiving the supplements, as compared to the placebo group (SMD: 0.72 pg/mL, 95% CI: 0.28, 1.15; P < 0.001) (I2 = 84.39%, P < 0.001). Sub-group analyses revealed similar findings in trials with fewer than 10 weeks, which utilized both animal (fish oil) and herbal (flaxseed) forms of omega-3 supplements with a high daily dosage of 2000mg.

Conclusion: The present systematic review and meta-analysis indicate the efficacy of omega-3 FAs in increasing the serum concentration of BDNF. Therefore, omega-3 FAs should be prioritized as agents for increasing BDNF in interventions.

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欧米茄-3 脂肪酸对脑源性神经营养因子 (BDNF) 影响的系统回顾和荟萃分析。

背景：欧米伽-3脂肪酸（ω-3 FAs）因其对脑源性神经营养因子（BDNF）循环水平的影响而受到研究人员的关注。我们的目的是对随机对照试验（RCT）进行系统回顾和元分析，以评估补充欧米伽-3 脂肪酸对血清 BDNF 浓度的影响：对Scopus、PubMed、Web of Science和Cochrane图书馆进行了系统检索，直至2023年4月。利用 Cochrane 偏倚风险评估工具对研究质量进行评估。采用随机效应模型，使用标准均值差（SMD）和95%置信区间（CI）估算BDNF水平的总体效应大小。研究之间的异质性采用卡方和I2统计量进行评估：结果：共纳入了 12 项研究，涉及 587 名受试者。与安慰剂组相比，补充 PUFA 与接受补充剂组血清中 BNDF 水平的显著增加有关（SMD：0.72 pg/mL，95% CI：0.28，1.15；P P 结论：本系统综述和荟萃分析表明，ω-3脂肪酸对提高BDNF的血清浓度具有疗效。因此，ω-3脂肪酸应优先作为增加BDNF的干预药物。

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来源期刊

Nutritional Neuroscience 医学-神经科学

CiteScore

8.50

自引率

2.80%

发文量

236

审稿时长

>12 weeks

期刊介绍： Nutritional Neuroscience is an international, interdisciplinary broad-based, online journal for reporting both basic and clinical research in the field of nutrition that relates to the central and peripheral nervous system. Studies may include the role of different components of normal diet (protein, carbohydrate, fat, moderate use of alcohol, etc.), dietary supplements (minerals, vitamins, hormones, herbs, etc.), and food additives (artificial flavours, colours, sweeteners, etc.) on neurochemistry, neurobiology, and behavioural biology of all vertebrate and invertebrate organisms. Ideally this journal will serve as a forum for neuroscientists, nutritionists, neurologists, psychiatrists, and those interested in preventive medicine.