Cross-Reactivity Between Propylene Glycol and Butylene Glycol.

IF 4 3区医学 Q1 DERMATOLOGY Dermatitis Pub Date : 2024-03-01 Epub Date: 2023-08-17 DOI:10.1089/derm.2023.0143

Samuel F Ekstein, Nicholas Battis, Dominick Dabrowski, Anne B Neeley

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Abstract

Background: Propylene glycol (PG) and butylene glycol (BG) are not known to be cross-reactors. However, no large-scale studies have assessed the cross-reactivity rate (CRR) between these 2 structurally and functionally similar compounds. Objectives: The aim of this study was to determine whether PG and BG demonstrate cross-reactivity. Methods: This is a retrospective chart review of 893 patients who underwent patch testing for both PG and BG from 2020 to 2022. The frequencies of positive reactions and concomitant reaction rates were calculated. Results: In our cohort, 53 (5.94%) patients reacted to PG and 13 patients (1.46%) reacted to BG. Of the patients who reacted to PG, 6 reacted to BG representing a CRR of 11.3%, whereas the CRR to PG in BG-allergic patients was 46.2%. Conclusions: For those allergic to BG, PG should be considered a cross-reactor. This relationship is somewhat unidirectional, as patients allergic to PG demonstrated a CRR to BG of only 11.3%, significantly lower than the 46.2% CRR to PG among BG-allergic patients.

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丙二醇与丁二醇之间的交叉反应。

背景：众所周知，丙二醇（PG）和丁二醇（BG）不会发生交叉反应。然而，还没有大规模的研究评估过这两种结构和功能相似的化合物之间的交叉反应率（CRR）。研究目的本研究旨在确定 PG 和 BG 是否会产生交叉反应。方法：这是一项回顾性病历审查：本研究对 2020 年至 2022 年期间接受 PG 和 BG 贴片测试的 893 名患者进行了回顾性病历审查。计算了阳性反应频率和伴随反应率。结果显示在我们的队列中，53 名患者（5.94%）对 PG 有反应，13 名患者（1.46%）对 BG 有反应。在对 PG 过敏的患者中，有 6 人对 BG 过敏，CRR 为 11.3%，而对 BG 过敏的患者对 PG 的 CRR 为 46.2%。结论：对 BG 过敏的患者应将 PG 视为交叉反应物。这种关系具有一定的单向性，因为对 PG 过敏的患者对 BG 的 CRR 仅为 11.3%，明显低于对 BG 过敏的患者对 PG 46.2% 的 CRR。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Dermatitis 医学-皮肤病学

CiteScore

5.30

自引率

11.50%

发文量

251

审稿时长

>12 weeks

期刊介绍： Dermatitis is owned by the American Contact Dermatitis Society and is the home journal of 4 other organizations, namely Societa Italiana di Dermatologica Allergologica Professionale e Ambientale, Experimental Contact Dermatitis Research Group, International Contact Dermatitis Research Group, and North American Contact Dermatitis Group. Dermatitis focuses on contact, atopic, occupational, and drug dermatitis, and welcomes manuscript submissions in these fields, with emphasis on reviews, studies, reports, and letters. Annual sections include Contact Allergen of the Year and Contact Allergen Alternatives, for which papers are chosen or invited by the respective section editor. Other sections unique to the journal are Pearls & Zebras, Product Allergen Watch, and news, features, or meeting abstracts from participating organizations.