Coriandrum sativum and Aloysia triphylla can Protect the Development of Cancer: An in Vivo Study using Mouse Painting Assay.

IF 2.3 4区医学 Q3 ONCOLOGY Current cancer drug targets Pub Date : 2024-01-01 DOI:10.2174/1568009623666230817101757

Omar F Khabour, Sawsan Abuhammad, Karem H Alzoubi, Ahmad S Alkofahi

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Abstract

Aim: The aim of this study is to examine the protective properties of Coriandrum sativum and Aloysia triphylla against the development of skin cancer.

Methods: The skin cancer balb/c mouse model was utilized in the study. Plant extracts were administered to animals using oral gavage. In addition, skin cancer was induced using 7,12-dimethylbenz( a) anthracene (DMBA).

Results: The study found that A. triphylla extract reduced both tumor incidence (P<0.01) and papilloma frequency (P<0.001) and delayed the onset of tumor development (P<0.001). The A. triphylla extract did not affect tumor size in animals. C. sativum leaf extract reduced the number of tumors per animal, the incidence of tumors, and the frequency of papilloma (P<0.05). In addition, it delayed (P<0.01) the onset of tumors. Treatment of animals with C. sativum seed extract reduced the frequency of papilloma (P<0.05) and delayed the onset of tumors (P<0.05). However, the examined plant extracts did not impact the size of tumors induced by DMBA (P>0.05).

Conclusion: The findings of this study revealed that C. sativum and A. triphylla could protect against cancer development as indicated using the animal model of skin painting assay.

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芫荽和三叶萝藦能保护癌症的发展：利用小鼠绘画试验进行的体内研究

目的：本研究旨在探讨芫荽和三叶木香对皮肤癌的保护作用：研究采用皮肤癌 balb/c 小鼠模型。方法：研究采用了皮肤癌 balb/c 小鼠模型，通过口服给动物服用植物提取物。此外，还使用 7,12-二甲基苯（a）蒽（DMBA）诱发皮肤癌：研究发现，A. triphylla 提取物降低了肿瘤发病率（P<0.01）和乳头状瘤发生率（P<0.001），并延缓了肿瘤的发生（P<0.001）。A. triphylla 提取物不会影响动物肿瘤的大小。荠菜叶提取物降低了每只动物的肿瘤数量、肿瘤发病率和乳头状瘤发生率（P<0.05）。此外，它还能延缓肿瘤的发生（P<0.01）。用 C. sativum 种子提取物处理动物可降低乳头状瘤的发生率（PP<0.05）。然而，所研究的植物提取物对 DMBA 诱导的肿瘤大小没有影响（P>0.05）：本研究的结果表明，荠菜和三叶芹可以防止癌症的发生，这一点可以通过皮肤涂色动物模型来证明。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current cancer drug targets 医学-肿瘤学

CiteScore

5.40

自引率

0.00%

发文量

105

审稿时长

1 months

期刊介绍： Current Cancer Drug Targets aims to cover all the latest and outstanding developments on the medicinal chemistry, pharmacology, molecular biology, genomics and biochemistry of contemporary molecular drug targets involved in cancer, e.g. disease specific proteins, receptors, enzymes and genes. Current Cancer Drug Targets publishes original research articles, letters, reviews / mini-reviews, drug clinical trial studies and guest edited thematic issues written by leaders in the field covering a range of current topics on drug targets involved in cancer. As the discovery, identification, characterization and validation of novel human drug targets for anti-cancer drug discovery continues to grow; this journal has become essential reading for all pharmaceutical scientists involved in drug discovery and development.