Epidemiology and drug susceptibility of nontuberculous mycobacteria (NTM) in Italy in 2016-2020.

IF 1.1 4区医学 Q4 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Annali dell'Istituto superiore di sanita Pub Date : 2023-04-01 DOI:10.4415/ANN_23_02_06

Federico Giannoni, Alessio Lanni, Angelo Iacobino, Lanfranco Fattorini

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引用次数: 1

Abstract

Introduction: Nontuberculous mycobacteria (NTM) are environmental mycobacteria which may cause pulmonary and extrapulmonary diseases. These organisms are difficult to treat due to their intrinsic drug-resistance. In Italy, no major nationwide study on NTM epidemiology and drug susceptibility was performed.

Methods: Data on the epidemiology of 7,469 NTM clinical isolates identified in Italy in 2016-2020 and on the minimum inhibitory concentrations (MICs) of 1,506 of these strains were analysed.

Results: Overall, 63 species were identified in 42 hospital laboratories located in 16 out of 20 regions, with Mycobacterium avium complex (MAC) being the most frequently isolated, followed by M. gordonae, M. xenopi, M. abscessus. The MICs of 12 drugs for MAC, M. xenopi, M. kansasii, M. abscessus, M. fortuitum and M. chelonae were interpreted for clinical significance (susceptible, intermediate, resistant) based on the guidelines published by the Clinical and Laboratory Standards Institute in November 2018.

Conclusions: Our data are in line with other nationwide studies and may be of value for further update of microbiological and clinical guidelines.

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意大利2016-2020年非结核分枝杆菌(NTM)流行病学及药敏分析

简介:非结核分枝杆菌(NTM)是一种可引起肺部和肺外疾病的环境分枝杆菌。这些微生物由于其固有的耐药性而难以治疗。在意大利，没有进行NTM流行病学和药物敏感性的重大全国性研究。方法:对意大利2016-2020年鉴定出的7469株NTM临床分离株的流行病学资料和其中1506株的最低抑菌浓度(mic)进行分析。结果:总体而言，在20个地区中的16个地区的42家医院实验室中鉴定出63种，其中鸟分枝杆菌复合体(MAC)是最常见的，其次是戈登分枝杆菌、xenopi分枝杆菌、脓肿分枝杆菌。根据临床与实验室标准协会2018年11月发布的指南，对MAC、xenopi、M. kansasii、M.脓肿、M. fortuitum和M. chelonae等12种药物的mic进行临床意义(敏感、中间、耐药)解读。结论:我们的数据与其他全国性研究一致，可能对进一步更新微生物学和临床指南有价值。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annali dell'Istituto superiore di sanita PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-

CiteScore

3.80

自引率

4.80%

发文量

审稿时长

>12 weeks

期刊介绍： Annali dell’Istituto Superiore di Sanità is a peer reviewed quarterly science journal which publishes research articles in biomedicine, translational research and in many other disciplines of the health sciences. The journal includes the following material: original articles, reviews, commentaries, editorials, brief and technical notes, book reviews. The publication of Monographic Sections has been discontinued. In case you wish to present a small number of coordinated contributions on specific themes concerning priorities in public health, please contact the Editorial office. The journal is in English.