Nonsterile Basics of Compounding: Compounding with Antioxidants, Part 1: An Overview.

Abstract

This article, which is part 1 of a series on compounding with antioxidants, discusses specific preparation methods and techniques along with packaging, storing, and labeling issues. Also presented are the allowable overages from the United States Pharmacopeia's discussion on "Commercial Parenteral Products". Some considerations related to potential issues when compounding with commercial products are also discussed using specific examples. The article ends with a discussion of product standardization and look-alike products. The formulation of an antioxidant system is accomplished primarily through trial and error. With some experimentation and patience, a suitable, stable system with the required characteristics can be obtained.