Ionically bridged dexamethasone sodium phosphate–zinc–PLGA nanocomplex in alginate microgel for the local treatment of ulcerative colitis

IF 6.9 3区 医学 Q1 CHEMISTRY, MEDICINAL Archives of Pharmacal Research Pub Date : 2023-08-03 DOI:10.1007/s12272-023-01456-z
Aruzhan Saparbayeva, Juho Lee, Shwe Phyu Hlaing, Jihyun Kim, Dongmin Kwak, Hyunwoo Kim, Eun Hee Lee, Seonghwan Hwang, Min-Soo Kim, Hyung Ryong Moon, Yunjin Jung, Jin-Wook Yoo
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引用次数: 1

Abstract

Colon-targeted oral drug delivery systems comprising nanoparticles and microparticles have emerged as promising tools for the treatment of ulcerative colitis (UC) because they minimize side effects and maximize the local drug concentration. Dexamethasone sodium phosphate (DSP) is a potent anti-inflammatory glucocorticoid used for the treatment of UC. However, it remains a rather short-term treatment option owing to its side effects. In the present study, we developed the alginate gel encapsulating ionically bridged DSP-zinc-poly(lactic-co-glycolic acid) (PLGA) nanocomplex (DZP-NCs-in-microgel) for the oral local treatment of UC. The successful encapsulation of DSP-zinc-PLGA nanocomplex (DZP-NCs) in alginate microgel was confirmed by SEM imaging. The prepared gel released DZP-NCs in the stimulated intestinal fluid and dampened the release of DSP in the upper gastrointestinal tract. Furthermore, DZP-NCs-in-microgel alleviated colonic inflammation in a mouse model of dextran sodium sulfate-induced colitis by relieving clinical symptoms and histological marks. Our results suggest a novel approach for the oral colon-targeted delivery of dexamethasone sodium phosphate for the treatment of UC.

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海藻酸盐微凝胶中离子桥接地塞米松磷酸钠-锌- plga纳米复合物局部治疗溃疡性结肠炎
由纳米颗粒和微颗粒组成的结肠靶向口服给药系统已成为治疗溃疡性结肠炎(UC)的有前途的工具,因为它们可以最大限度地减少副作用并最大化局部药物浓度。地塞米松磷酸钠(DSP)是一种有效的抗炎糖皮质激素,用于治疗UC。然而,由于其副作用,它仍然是一个相当短期的治疗选择。在本研究中,我们开发了海藻酸盐凝胶包封离子桥接的dsp -锌-聚乳酸-羟基乙酸(PLGA)纳米复合物(DZP-NCs-in-microgel),用于口腔局部治疗UC。扫描电镜(SEM)证实了海藻酸盐微凝胶成功包封了dsp - zn - plga纳米复合物(dzp - nc)。制备的凝胶在受刺激的肠液中释放DZP-NCs,并抑制上消化道DSP的释放。此外,dzp - ncs -in微凝胶通过缓解临床症状和组织学标记,减轻了右旋糖酐硫酸钠诱导结肠炎小鼠模型的结肠炎症。我们的研究结果提出了一种口服结肠靶向递送地塞米松磷酸钠治疗UC的新方法。
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来源期刊
CiteScore
13.40
自引率
9.00%
发文量
48
审稿时长
3.3 months
期刊介绍: Archives of Pharmacal Research is the official journal of the Pharmaceutical Society of Korea and has been published since 1976. Archives of Pharmacal Research is an interdisciplinary journal devoted to the publication of original scientific research papers and reviews in the fields of drug discovery, drug development, and drug actions with a view to providing fundamental and novel information on drugs and drug candidates.
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