Asociación del consumo de drogas ilícitas en mujeres embarazadas y sífilis congénita en un Hospital Público de México

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2024-01-01 DOI:10.1016/j.ram.2023.07.002

Lucía Miramontes-Buiza , Juan Carlos Lona-Reyes , Rene Oswaldo Pérez-Ramírez , Diego Magallón-Picazo , Araceli Cordero-Zamora , Larissa María Gómez-Ruiz , Tania Alejandra Cruz-Chávez

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Abstract

We conducted a nested case–control study within a cohort with the aim of studying the association between illicit drug use and congenital syphilis (CS). Cases were diagnosed based on treponemal and non-treponemal tests conducted both in the mother and the newborn (NB). Multivariate analysis with logistic regression was performed. A total of 6171 births with a mean gestational age of 37.8 weeks were recorded and 62 CS events were diagnosed (incidence 10.5 events/1000 NB). Associated maternal factors were illicit drug use (OR 14.08, 95% CI 1.19–166.6), <5 prenatal visits (OR 2.9, 95% CI 1.12–7.53), more than two sexual partners (OR 3.76, 95% CI 1.62–8.71) and professional education level (OR 0.06, 95% CI 0.005–0.85). Among the mothers of the cases presented, the prevalence of illicit drug use was 22.6% and the most frequent drugs were methamphetamines and cannabis.

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墨西哥一家公立医院中孕妇使用非法药物与先天性梅毒的关系。

我们在一个队列中开展了一项巢式病例对照研究，目的是研究使用非法药物与先天性梅毒（CS）之间的关系。病例的诊断依据是对母亲和新生儿（NB）进行的梅毒试验和非梅毒试验。采用逻辑回归法进行多变量分析。共记录了 6171 例新生儿，平均胎龄为 37.8 周，诊断出 62 例 CS（发病率为 10.5 例/1000 名新生儿）。与此相关的产妇因素包括使用非法药物（OR 14.08，95% CI 1.19-166.6）、5 次产前检查（OR 2.9，95% CI 1.12-7.53）、两个以上性伴侣（OR 3.76，95% CI 1.62-8.71）和专业教育水平（OR 0.06，95% CI 0.005-0.85）。在这些病例的母亲中，使用非法药物的比例为 22.6%，最常使用的药物是甲基苯丙胺和大麻。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.

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