Sex as a Biological Variable in Nutrition Research: From Human Studies to Animal Models.

IF 12.6 2区 医学 Q1 NUTRITION & DIETETICS Annual review of nutrition Pub Date : 2022-08-22 DOI:10.1146/annurev-nutr-062220-105852
Yilin Chen, Minhoo Kim, Sanjana Paye, Bérénice A Benayoun
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引用次数: 7

Abstract

Biological sex is a fundamental source of phenotypic variability across species. Males and females have different nutritional needs and exhibit differences in nutrient digestion and utilization, leading to different health outcomes throughout life. With personalized nutrition gaining popularity in scientific research and clinical practice, it is important to understand the fundamentals of sex differences in nutrition research. Here, we review key studies that investigate sex dimorphism in nutrition research: sex differences in nutrient intake and metabolism, sex-dimorphic response in nutrient-restricted conditions, and sex differences in diet and gut microbiome interactions. Within each area above, factors from sex chromosomes, sex hormones, and sex-specific loci are highlighted.

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性别作为营养研究中的生物变量:从人体研究到动物模型。
生物性别是物种间表型变异的一个基本来源。男性和女性有不同的营养需求,在营养消化和利用方面表现出差异,导致一生中不同的健康结果。随着个性化营养在科学研究和临床实践中越来越受欢迎,了解营养研究中性别差异的基本原理非常重要。在此,我们回顾了研究营养研究中性别二态性的关键研究:营养摄入和代谢的性别差异,营养受限条件下的性别二态反应,饮食和肠道微生物群相互作用的性别差异。在上面的每个区域中,来自性染色体、性激素和性别特异性基因座的因素都被突出显示。
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来源期刊
Annual review of nutrition
Annual review of nutrition 医学-营养学
CiteScore
15.80
自引率
0.00%
发文量
19
期刊介绍: Annual Review of Nutrition Publication History:In publication since 1981 Scope:Covers significant developments in the field of nutrition Topics Covered Include: Energy metabolism; Carbohydrates; Lipids; Proteins and amino acids; Vitamins; Minerals; Nutrient transport and function; Metabolic regulation; Nutritional genomics; Molecular and cell biology; Clinical nutrition; Comparative nutrition; Nutritional anthropology; Nutritional toxicology; Nutritional microbiology; Epidemiology; Public health nutrition
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