Clinicomycological Profile and Risk Factors for Dermatophytosis at a Teaching Tertiary Care Centre in North India: A Cross-sectional Study.

Q3 Pharmacology, Toxicology and Pharmaceutics Infectious disorders drug targets Pub Date : 2023-01-01 DOI:10.2174/1871526523666230428110207
Pooja Singla, Sima Garg, Prashant Singh, Nidhi R Sharma, Pratibha Mane, N K Singh, Sudhanshu Sharma
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Abstract

Background: Dermatophytosis has gained significant importance in recent years owing to increased incidence, more atypical lesions, changing mycological profile and growing antifungal resistance. Therefore, this study was planned to know the clinicomycological profile of dermatophytic infections in patients attending our tertiary care centre.

Materials and methods: A total of 700 patients with superficial fungal infections belonging to all age groups and both sexes were taken up for this cross-sectional study. Sociodemographic and clinical details were noted on a prestructured proforma. Superficial lesions were clinically examined and the sample was collected by appropriate collection methods. Direct microscopy by potassium hydroxide wet mount was done to see hyphae. For culture Sabouraud's dextrose agar (SDA) with chloramphenicol and cyclohexamide was used.

Results: Dermatophytic infections were detected in 75.8% (531/700) patients. Young people belonging to age group of 21-30 years were commonly affected. Tinea corporis was the commonest clinical picture seen in 20% of the cases. Oral antifungals were taken by 33.1% and topical creams were used by 74.2% of the patients. Direct microscopy was positive in 91.3% and culture was positive for dermatophytes in 61% of the study subjects. T. mentagrophytes was the commonest dermatophyte isolated.

Conclusion: Irrational use of topical steroids needs to be controlled. KOH microscopy can be useful as a point of care test for rapid screening of dermatophytic infections. Culture is necessary to differentiate various dermatophytes and to guide the antifungal treatment.

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临床菌学概况和风险因素的皮肤癣在印度北部的教学三级护理中心:横断面研究。
背景:近年来,由于发病率增加、非典型病变增多、真菌学特征改变和抗真菌性增强,皮肤真菌病变得越来越重要。因此,本研究计划了解在我们三级保健中心就诊的患者皮肤真菌感染的临床菌学概况。材料和方法:本横断面研究共纳入700例浅表真菌感染患者,属于所有年龄组和两性。社会人口学和临床细节记录在预结构的形式表上。临床检查浅表病变,采用适当的采集方法采集标本。用氢氧化钾湿载直接显微镜观察菌丝。采用氯霉素和环己胺对沙伯劳德葡萄糖琼脂(SDA)进行培养。结果:75.8%(531/700)患者检出皮肤真菌感染。21-30岁的年轻人是最常见的患者。体癣是最常见的临床表现,占20%的病例。口服抗真菌药物占33.1%,外用药膏占74.2%。直接显微镜检查结果为91.3%,皮肤真菌培养结果为61%。分离到的皮癣菌中最常见的是mentagrophytes。结论:应控制局部类固醇药物的不合理使用。KOH显微镜可作为一个点护理试验,用于快速筛选皮肤真菌感染。培养是区分各种皮肤真菌和指导抗真菌治疗的必要条件。
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来源期刊
Infectious disorders drug targets
Infectious disorders drug targets Pharmacology, Toxicology and Pharmaceutics-Pharmacology
CiteScore
3.10
自引率
0.00%
发文量
123
期刊介绍: Infectious Disorders - Drug Targets aims to cover all the latest and outstanding developments on the medicinal chemistry, pharmacology, molecular biology, genomics and biochemistry of contemporary molecular targets involved in infectious disorders e.g. disease specific proteins, receptors, enzymes, genes. Each issue of the journal contains a series of timely in-depth reviews written by leaders in the field covering a range of current topics on drug targets involved in infectious disorders. As the discovery, identification, characterization and validation of novel human drug targets for anti-infective drug discovery continues to grow, this journal will be essential reading for all pharmaceutical scientists involved in drug discovery and development.
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