Variant-specific Symptoms After COVID-19: A Hospital-based Study in Hiroshima.

IF 3.7 2区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Journal of Epidemiology Pub Date : 2024-05-05 Epub Date: 2023-10-31 DOI:10.2188/jea.JE20230103
Kanon Abe, Aya Sugiyama, Noriaki Ito, Kei Miwata, Yoshihiro Kitahara, Mafumi Okimoto, Ulugbek Mirzaev, Akemi Kurisu, Tomoyuki Akita, Ko Ko, Kazuaki Takahashi, Tatsuhiko Kubo, Toshiro Takafuta, Junko Tanaka
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引用次数: 0

Abstract

Background: Symptoms after novel coronavirus disease 2019 (COVID-19) recovery by severe acute respiratory syndrome coronavirus 2 strains are unspecified.

Methods: This self-administered questionnaire-based study was conducted to investigate symptoms after COVID-19 recovery at one of the main hospitals for COVID-19 treatment in Hiroshima, Japan, from September 2020 to March 2022 for patients who visited follow-up consultations after COVID-19. Study subjects were divided into four groups (Wild-type, Alpha, Delta, and Omicron periods) according to COVID-19 onset date. Hierarchical cluster analysis was performed to determine symptom clusters and investigate risk factors for each symptom cluster using multivariate analysis.

Results: Among 385 patients who enrolled in this study, 249 patients had any persistent symptoms at a median of 23.5 (interquartile range, 20-31) days after COVID-19 onset. Among patients with any persistent symptoms, symptom clusters including olfactory or taste disorders, respiratory symptoms, and cardiac symptoms were found. Respiratory symptoms were more frequent among patients infected in the Omicron period compared to the Wild-type period (adjusted odds ratio [AOR] 3.13; 95% confidence interval [CI], 1.31-7.48). Compared to patients who recovered from mild COVID-19, patients who needed oxygen or ventilation support suffered fewer post-COVID-19 respiratory symptoms (AOR 0.46; 95% CI, 0.22-0.97) but more post-COVID-19 cardiac symptoms among them (AOR 2.67; 95% CI, 1.26-5.65). Olfactory or taste disorders were fewer among patients infected in the Omicron period compared to the Wild-type period (AOR 0.14; 95% CI, 0.04-0.46).

Conclusion: This study revealed that symptoms after COVID-19 may vary depending on the infected strain.

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COVID-19 后的变异特异性症状:广岛医院研究
背景:新型冠状病毒病2019(COVID-19)由严重急性呼吸综合征冠状病毒2株恢复后症状不明:严重急性呼吸系统综合征冠状病毒 2 株新型冠状病毒病 2019(COVID-19)康复后的症状不明:2020年9月至2022年3月期间,在日本广岛治疗COVID-19的一家主要医院对COVID-19康复后的症状进行了调查。研究对象根据 COVID-19 发病日期分为四组(野生型、α、δ和Ω期)。采用层次聚类分析确定症状群,并通过多变量分析研究每个症状群的风险因素:在385名参与研究的患者中,有249名患者在COVID-19发病后23.5天(四分位间范围为20-31天)出现持续症状。在出现任何持续症状的患者中,发现了包括嗅觉或味觉障碍、呼吸道症状和心脏症状在内的症状群。与野生型患者相比,欧米克隆期感染者的呼吸道症状更为常见(调整后的几率比[AOR]为 3.13;95% 置信区间[CI]为 1.31-7.48)。与从轻度 COVID-19 中恢复的患者相比,需要氧气或通气支持的患者在 COVID-19 后出现的呼吸系统症状较少(AOR 0.46;95% CI,0.22-0.97),但他们在 COVID-19 后出现的心脏症状较多(AOR 2.67;95% CI,1.26-5.65)。与野生型患者相比,奥米克龙期感染者的嗅觉或味觉障碍较少(AOR 0.14;95% CI,0.04-0.46):本研究表明,COVID-19感染后的症状可能因感染菌株的不同而有所差异。
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来源期刊
Journal of Epidemiology
Journal of Epidemiology 医学-公共卫生、环境卫生与职业卫生
CiteScore
7.50
自引率
4.30%
发文量
172
审稿时长
6-12 weeks
期刊介绍: The Journal of Epidemiology is the official open access scientific journal of the Japan Epidemiological Association. The Journal publishes a broad range of original research on epidemiology as it relates to human health, and aims to promote communication among those engaged in the field of epidemiological research and those who use epidemiological findings.
期刊最新文献
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