Functional Roles of lncRNAs in Recurrent Pregnancy Loss: A Review Study.

IF 2.3 Q2 OBSTETRICS & GYNECOLOGY International Journal of Fertility & Sterility Pub Date : 2023-08-07 DOI:10.22074/ijfs.2022.559132.1339
Shirin Azizidoost, Mahrokh Abouali Gale Dari, Farhoodeh Ghaedrahmati, Zahra Razani, Mona Keivan, Razieh Mohammad Jafari, Mahin Najafian, Maryam Farzaneh
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引用次数: 1

Abstract

Recurrent pregnancy loss (RPL) or recurrent miscarriage is the failure of pregnancy before 20-24 weeks that influences around 2-5% of couples. Several genetic, immunological, environmental and physical factors may influence RPL. Although various traditional methods have been used to treat post-implantation failures, identifying the mechanisms underlying RPL may improve an effective treatment. Recent evidence suggested that gene expression alterations presented essential roles in the occurrence of RPL. It has been found that long non-coding RNAs (lncRNAs) play functional roles in pregnancy pathologies, such as recurrent miscarriage. lncRNAs can function as dynamic scaffolds, modulate chromatin function, guide and bind to microRNAs (miRNAs) or transcription factors. lncRNAs, by targeting various miRNAs and mRNAs, play essential roles in the progression or suppression of RPL. Therefore, targeting lncRNAs and their downstream targets might be a suitable strategy for diagnosis and treatment of RPL. In this review, we summarized emerging roles of several lncRNAs in stimulation or suppression of RPL.

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lncRNA在复发性妊娠丢失中的功能作用:一项综述性研究。
复发性妊娠损失(RPL)或复发性流产是指20-24周前妊娠失败,约2-5%的夫妇受到影响。多种遗传、免疫、环境和物理因素可能影响RPL。尽管已经使用了各种传统方法来治疗植入后失败,但确定RPL的潜在机制可能会提高有效的治疗效果。最近的证据表明,基因表达的改变在RPL的发生中起着重要作用。已经发现,长非编码RNA(lncRNA)在妊娠病理中发挥功能作用,如复发性流产。lncRNA可以作为动态支架,调节染色质功能,引导和结合微小RNA(miRNA)或转录因子。lncRNA通过靶向各种miRNA和mRNA,在RPL的进展或抑制中发挥重要作用。因此,靶向lncRNA及其下游靶点可能是诊断和治疗RPL的合适策略。在这篇综述中,我们总结了几种lncRNA在刺激或抑制RPL中的新作用。
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来源期刊
CiteScore
4.20
自引率
0.00%
发文量
68
审稿时长
>12 weeks
期刊介绍: International Journal of Fertility & Sterility is a quarterly English publication of Royan Institute . The aim of the journal is to disseminate information through publishing the most recent scientific research studies on Fertility and Sterility and other related topics. Int J Fertil Steril has been certified by Ministry of Culture and Islamic Guidance in 2007 and was accredited as a scientific and research journal by HBI (Health and Biomedical Information) Journal Accreditation Commission in 2008. Int J Fertil Steril is an Open Access journal.
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