Hypertension and Histopathology Severity of Non-Alcoholic Fatty Liver Disease Among Adults with Obesity: A Cross-Sectional Study.

IF 2.5 Q2 GASTROENTEROLOGY & HEPATOLOGY Clinical and Experimental Gastroenterology Pub Date : 2023-01-01 DOI:10.2147/CEG.S402498
Diego Chambergo-Michilot, Paola K Rodrigo-Gallardo, Mariella R Huaman, Angie Z Vasquez-Chavesta, Gustavo Salinas-Sedo, Carlos J Toro-Huamanchumo
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引用次数: 1

Abstract

Background: Cardiovascular diseases are responsible for the majority of deaths resulting from non-alcoholic fatty liver disease (NAFLD). NAFLD is associated with hypertension and this is a key predictor of severe liver outcomes and an indicator of nonspecific portal fibrosis.

Aim: To assess the association between hypertension and NAFLD severity.

Methods: We conducted a secondary analysis of data from Peruvian adults with obesity and NAFLD who attended a Peruvian bariatric center. The severity of NAFLD was assessed using the Fatty Liver Inhibition of Progression algorithm / Steatosis, Activity and Fibrosis score. Hypertension was determined by either being recorded in the medical records or if the patient had a systolic pressure ≥ 140 mmHg or diastolic pressure ≥ 90 mmHg. To evaluate the association of interest, we calculated crude and adjusted prevalence ratios (aPR) using Poisson generalized linear models with logarithmic link function and robust variances. For the multivariable models, we adjusted for age, sex, physical activity and smoking.

Results: Our study included 234 participants. The prevalence of hypertension was 19.2%, while the prevalence of severe NAFLD was 46.2%. After adjusting for confounders, the prevalence of hypertension was found to be significantly higher in the severe NAFLD group compared to the non-severe group (aPR = 1.33; 95% CI: 1.03-1.74). When stratified by the presence of metabolic syndrome (MetS), the association remained significant only in the group without MetS (aPR = 1.80; 95% CI: 1.05-3.11).

Conclusion: We found an association between hypertension and severe NAFLD in adults with obesity, particularly in those without MetS.

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肥胖成人非酒精性脂肪性肝病的高血压和组织病理学严重程度:一项横断面研究
背景:心血管疾病是导致非酒精性脂肪性肝病(NAFLD)死亡的主要原因。NAFLD与高血压相关,这是严重肝脏结局的关键预测因子和非特异性门脉纤维化的指标。目的:探讨高血压与NAFLD严重程度的关系。方法:我们对秘鲁肥胖和NAFLD成年人在秘鲁减肥中心就诊的数据进行了二次分析。使用脂肪肝抑制进展算法/脂肪变性、活动性和纤维化评分来评估NAFLD的严重程度。高血压是通过记录在医疗记录或患者收缩压≥140 mmHg或舒张压≥90 mmHg来确定的。为了评估兴趣相关性,我们使用带对数链接函数和稳健方差的泊松广义线性模型计算了粗患病率和调整患病率(aPR)。对于多变量模型,我们调整了年龄、性别、身体活动和吸烟。结果:我们的研究包括234名参与者。高血压患病率为19.2%,重度NAFLD患病率为46.2%。在调整混杂因素后,发现重度NAFLD组的高血压患病率明显高于非重度NAFLD组(aPR = 1.33;95% ci: 1.03-1.74)。当根据代谢综合征(MetS)的存在进行分层时,只有在没有MetS的组中,这种关联仍然显著(aPR = 1.80;95% ci: 1.05-3.11)。结论:我们发现高血压与肥胖成人严重NAFLD之间存在关联,特别是那些没有MetS的成年人。
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来源期刊
Clinical and Experimental Gastroenterology
Clinical and Experimental Gastroenterology GASTROENTEROLOGY & HEPATOLOGY-
CiteScore
5.10
自引率
0.00%
发文量
26
审稿时长
16 weeks
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