Unfolded Protein Response Signaling in Hepatic Stem Cell Activation in Liver Fibrosis.

IF 1.9 4区生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY Current protein & peptide science Pub Date : 2024-01-01 DOI:10.2174/1389203724666230822085951

Zohreh Salimi, Mehdi Rostami, Yaser Eshaghi Milasi, Alireza Mafi, Ramin Raoufinia, Amirhossein Kiani, Fariba Sakhaei, Behrooz Ghezelbash, Alexandra E Butler, Maryam Mohammad-Sadeghipour, Amirhossein Sahebkar

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Abstract

Frequent exposure to various external and internal adverse forces (stresses) disrupts cell protein homeostasis through endoplasmic reticulum (ER) capacity saturation. This process leads to the unfolded protein response (UPR), which aims to re-establish/maintain optimal cellular equilibrium. This complex mechanism is involved in the pathogenesis of various disorders, such as metabolic syndrome, fibrotic diseases, neurodegeneration, and cancer, by altering cellular metabolic changes integral to activating the hepatic stellate cells (HSCs). The development of hepatic fibrosis is one of the consequences of UPR activation. Therefore, novel therapies that target the UPR pathway effectively and specifically are being studied. This article covers the involvement of the UPR signaling pathway in cellular damage in liver fibrosis. Investigating the pathogenic pathways related to the ER/UPR stress axis that contribute to liver fibrosis can help to guide future drug therapy approaches.

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肝纤维化中肝脏干细胞活化过程中的折叠蛋白反应信号传导

频繁暴露于各种外部和内部不利力量（压力）之下，会导致内质网（ER）容量饱和，从而破坏细胞蛋白质的平衡。这一过程导致了旨在重建/维持最佳细胞平衡的未折叠蛋白反应（UPR）。这种复杂的机制通过改变激活肝星状细胞（HSCs）不可或缺的细胞代谢变化，参与了代谢综合征、纤维化疾病、神经变性和癌症等各种疾病的发病机制。肝纤维化的发展是 UPR 激活的后果之一。因此，针对 UPR 通路进行有效和特异性治疗的新型疗法正在研究之中。本文介绍了 UPR 信号通路参与肝纤维化中细胞损伤的情况。研究与导致肝纤维化的ER/UPR应激轴相关的致病途径有助于指导未来的药物治疗方法。

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来源期刊

Current protein & peptide science 生物-生化与分子生物学

CiteScore

5.20

自引率

0.00%

发文量

审稿时长

6 months

期刊介绍： Current Protein & Peptide Science publishes full-length/mini review articles on specific aspects involving proteins, peptides, and interactions between the enzymes, the binding interactions of hormones and their receptors; the properties of transcription factors and other molecules that regulate gene expression; the reactions leading to the immune response; the process of signal transduction; the structure and function of proteins involved in the cytoskeleton and molecular motors; the properties of membrane channels and transporters; and the generation and storage of metabolic energy. In addition, reviews of experimental studies of protein folding and design are given special emphasis. Manuscripts submitted to Current Protein and Peptide Science should cover a field by discussing research from the leading laboratories in a field and should pose questions for future studies. Original papers, research articles and letter articles/short communications are not considered for publication in Current Protein & Peptide Science.