Uncommon Location for a Common Disease, Simulating Cervical Cancer: A Rare Case Report.

Q3 Pharmacology, Toxicology and Pharmaceutics Infectious disorders drug targets Pub Date : 2024-01-01 DOI:10.2174/1871526523666230822155148
Naina Kumar, Kanikaram Poojitha Kalyani, Abhimanyu Sharma, Sumitra Sivakoti, Mishu Mangla
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Abstract

Background: Genital tuberculosis (GTB) is a common form of extra-pulmonary TB with cervical TB being a rare entity accounting for 0.1-0.65% of all TB cases globally. It is usually asymptomatic but may present with infertility, menstrual irregularities, dyspareunia, dysmenorrhoea, or vaginal discharge.

Case presentation: The present case report briefs about a 39 years old nulliparous infertile woman who presented with complaints of irregular menstrual cycles and amenorrhea with an erosive papillary growth over the cervix simulating invasive cervical carcinoma. Her Pap smear report revealed the presence of granulomas. On cervical punch biopsy also a large number of granulomas were seen and on Ziehl Nielsen staining the diagnosis of TB was further confirmed by the presence of acid-fast rodlike bacilli. The patient responded well to anti-tubercular drugs.

Discussion: GTB in most of the cases remains asymptomatic with infertility being the most common presenting complaint. Other symptoms include menstrual irregularities, amenorrhoea, dysmenorrhoea, dyspareunia, chronic pelvic pain, and occasionally abnormal vaginal discharge. Tuberculous cervicitis is difficult to diagnose clinically and many times mimics cervical malignancy.

Result and conclusion: Hence, cervical tuberculosis should be kept in the differential diagnosis of cervical cancer especially in an infertile woman from a developing country.

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常见疾病的不常见部位,模拟宫颈癌:罕见病例报告
背景:生殖器结核(GTB)是肺外结核病的一种常见形式,而宫颈结核是一种罕见病,占全球结核病例的 0.1-0.65%。它通常没有症状,但可能表现为不孕、月经不调、痛经、痛经或阴道分泌物:本病例报告简要介绍了一位 39 岁的无子宫不孕妇女,她主诉月经周期不规律和闭经,宫颈上有类似浸润性宫颈癌的糜烂性乳头状增生。她的巴氏涂片报告显示存在肉芽肿。宫颈穿刺活检时也发现了大量肉芽肿,经齐氏尼尔森染色,发现了耐酸棒状杆菌,进一步证实了结核病的诊断。患者对抗结核药物反应良好:讨论:大多数 GTB 病例没有症状,不孕是最常见的主诉。其他症状包括月经不调、闭经、痛经、排尿困难、慢性盆腔疼痛,偶尔还会出现阴道分泌物异常。结核性宫颈炎在临床上很难诊断,很多时候会模仿宫颈恶性肿瘤:因此,在宫颈癌的鉴别诊断中应保留宫颈结核,尤其是发展中国家的不孕妇女。
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来源期刊
Infectious disorders drug targets
Infectious disorders drug targets Pharmacology, Toxicology and Pharmaceutics-Pharmacology
CiteScore
3.10
自引率
0.00%
发文量
123
期刊介绍: Infectious Disorders - Drug Targets aims to cover all the latest and outstanding developments on the medicinal chemistry, pharmacology, molecular biology, genomics and biochemistry of contemporary molecular targets involved in infectious disorders e.g. disease specific proteins, receptors, enzymes, genes. Each issue of the journal contains a series of timely in-depth reviews written by leaders in the field covering a range of current topics on drug targets involved in infectious disorders. As the discovery, identification, characterization and validation of novel human drug targets for anti-infective drug discovery continues to grow, this journal will be essential reading for all pharmaceutical scientists involved in drug discovery and development.
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