NEW DATA ON HISTOGENESIS AND HISTOLOGICAL STRUCTURE OF LUNG CANCER.

Q3 Medicine Experimental oncology Pub Date : 2023-06-26 DOI:10.15407/exp-oncology.2023.01.062

L Bolgova, A Shypko, T Tuganova, O Alekseenko, I Smolanka, A Ponomarenko, N Bilko

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Abstract

Background: Lung cancer (LC) is one of the most common malignant neoplasms in men around the world, which poses a number of important challenges for scientists.

Aim: To analyze the histogenesis, features of the histological structure, and growth of LC.

Materials and methods: The surgical material of 81 patients with LC was studied. Histological preparations were stained with hematoxylin and eosin (H&E) using the Papanicolaou method. Immunohistochemical reactions with monoclonals (Ki67, PCNA) were conducted.

Results: In histological preparations of all LC types (squamous, adenocarcinoma, and small cell), along with solid growth, tumor growth in the alveoli was determined, which started from the basal membrane and grew toward the alveolus center, as evidenced by the morphological features of growth, tumor spread, and development of necrosis in the center.

Conclusion: In all the studied histological preparations of LC, tumor growth in the alveoli is noted, which is confirmed by structural and cellular signs and the nature of tumor decay in the alveolus center, which corresponds to the general patterns of development of malignant epithelial tumors.

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肺癌组织发生及组织学结构的新资料。

背景:肺癌(LC)是世界范围内男性最常见的恶性肿瘤之一，这给科学家们提出了许多重要的挑战。目的:分析LC的组织发生、组织结构特点及生长情况。材料与方法:对81例LC患者的手术材料进行研究。采用帕帕尼科劳法对组织组织进行苏木精和伊红染色。单克隆(Ki67, PCNA)进行免疫组化反应。结果:在所有LC类型(鳞状、腺癌、小细胞)的组织学准备中，肿瘤在肺泡内随实体生长而生长，肿瘤从基底膜开始向肺泡中心生长，表现为生长、肿瘤扩散、中心坏死发展的形态学特征。结论:在LC的所有组织学制备中，肿瘤均在肺泡内生长，结构和细胞征象以及肺泡中心肿瘤衰变的性质证实了这一点，这符合恶性上皮肿瘤的一般发展模式。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Experimental oncology Medicine-Oncology

CiteScore

1.40

自引率

0.00%

发文量

期刊介绍： The Experimental Oncology is an English-language journal that publishes review articles, original contributions, short communications, case reports and technical advances presenting new data in the field of experimental and fundamental oncology. Manuscripts should be written in English, contain original work, which has not been published or submitted for publication elsewhere. It also implies the transfer of the Copyright from the author to “Experimental Oncology”. No part of journal publications may be reproduced, stored in a retrieval system or transmitted in any form or by any means without the prior permission of the publisher.