{"title":"The Role of Positron Emission Tomography for the Management of Sinonasal Malignancies: A Systematic Review.","authors":"David El-Adem, Nathan Yang, David A Gudis","doi":"10.1177/19458924231177854","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Positron emission tomography (PET) scan is a valuable imaging modality widely used in the management of cancers. Its usage is well defined for most head and neck malignancies. However, there is a lack of consensus regarding the utility of PET scan for sinonasal malignancies. This is highlighted by the latest international consensus statement on endoscopic skull base surgery.</p><p><strong>Objective: </strong>This systematic review aims to clarify the role of PET scan in the management of sinonasal malignancies.</p><p><strong>Methods: </strong>We conducted a comprehensive literature search using PubMed, MEDLINE, EMBASE, Web of Science, CINAHL, and Cochrane databases for research studies of interest. The Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) updated statement was used to guide the review.</p><p><strong>Results: </strong>In total, 1807 articles were assessed for eligibility. Thirty-nine original papers, published between 2004 and 2021, met inclusion criteria. Seven articles focused on the role of PET scan for inverted papilloma, 23 for sinonasal carcinoma, 4 for melanoma, and 3 for lymphoma, and finally, 3 articles focused on the use of specific PET scan tracers for sinonasal malignancies. Qualitative summaries for each potential role of PET scans were provided. In general, included studies were retrospective in nature with low level of evidence.</p><p><strong>Conclusions: </strong>In general, and across all types of sinonasal malignancies, PET scan yielded positive results regarding detection and initial staging. It was also considered as the modality of choice for detection of distant metastases, except in the case of sinonasal lymphoma. PET scan's main limit resides in its inability to detect lesions in or close to the metabolic activity of the brain.</p>","PeriodicalId":7650,"journal":{"name":"American Journal of Rhinology & Allergy","volume":"37 5","pages":"593-610"},"PeriodicalIF":2.5000,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10433402/pdf/","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"American Journal of Rhinology & Allergy","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1177/19458924231177854","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"OTORHINOLARYNGOLOGY","Score":null,"Total":0}
引用次数: 1
Abstract
Background: Positron emission tomography (PET) scan is a valuable imaging modality widely used in the management of cancers. Its usage is well defined for most head and neck malignancies. However, there is a lack of consensus regarding the utility of PET scan for sinonasal malignancies. This is highlighted by the latest international consensus statement on endoscopic skull base surgery.
Objective: This systematic review aims to clarify the role of PET scan in the management of sinonasal malignancies.
Methods: We conducted a comprehensive literature search using PubMed, MEDLINE, EMBASE, Web of Science, CINAHL, and Cochrane databases for research studies of interest. The Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) updated statement was used to guide the review.
Results: In total, 1807 articles were assessed for eligibility. Thirty-nine original papers, published between 2004 and 2021, met inclusion criteria. Seven articles focused on the role of PET scan for inverted papilloma, 23 for sinonasal carcinoma, 4 for melanoma, and 3 for lymphoma, and finally, 3 articles focused on the use of specific PET scan tracers for sinonasal malignancies. Qualitative summaries for each potential role of PET scans were provided. In general, included studies were retrospective in nature with low level of evidence.
Conclusions: In general, and across all types of sinonasal malignancies, PET scan yielded positive results regarding detection and initial staging. It was also considered as the modality of choice for detection of distant metastases, except in the case of sinonasal lymphoma. PET scan's main limit resides in its inability to detect lesions in or close to the metabolic activity of the brain.
背景:正电子发射断层扫描(PET)是一种有价值的成像方式，广泛应用于癌症的治疗。对于大多数头颈部恶性肿瘤，它的用法是明确的。然而，关于PET扫描在鼻窦恶性肿瘤中的应用还缺乏共识。这是强调了最新的国际共识声明内窥镜颅底手术。目的:本系统综述旨在阐明PET扫描在鼻窦恶性肿瘤治疗中的作用。方法:我们使用PubMed、MEDLINE、EMBASE、Web of Science、CINAHL和Cochrane数据库对感兴趣的研究进行了全面的文献检索。采用系统评价和荟萃分析首选报告项目(PRISMA)更新声明来指导评价。结果:共有1807篇文章被评估为合格。2004年至2021年间发表的39篇原创论文符合纳入标准。7篇文章聚焦于PET扫描在内翻性乳头状瘤中的作用，23篇聚焦于鼻窦癌，4篇聚焦于黑色素瘤，3篇聚焦于淋巴瘤，最后3篇聚焦于特定PET扫描示踪剂在鼻窦恶性肿瘤中的应用。定性总结了PET扫描的每个潜在作用。总的来说，纳入的研究是回顾性的，证据水平低。结论:总的来说，在所有类型的鼻窦恶性肿瘤中，PET扫描在检测和初始分期方面产生了阳性结果。除了鼻窦淋巴瘤外，它也被认为是检测远处转移的首选方式。PET扫描的主要限制在于它无法检测到大脑代谢活动内部或附近的病变。
期刊介绍：
The American Journal of Rhinology & Allergy is a peer-reviewed, scientific publication committed to expanding knowledge and publishing the best clinical and basic research within the fields of Rhinology & Allergy. Its focus is to publish information which contributes to improved quality of care for patients with nasal and sinus disorders. Its primary readership consists of otolaryngologists, allergists, and plastic surgeons. Published material includes peer-reviewed original research, clinical trials, and review articles.
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