Hepatic steatosis using ultrasound-derived fat fraction: First technical and clinical evaluation.

IF 2.1 4区医学 Q3 HEMATOLOGY Clinical hemorheology and microcirculation Pub Date : 2024-01-01 DOI:10.3233/CH-238102

Yun-Lin Huang, Juan Cheng, Ying Wang, Xin-Liang Xu, Shi-Wen Wang, Li Wei, Yi Dong

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Abstract

Objectives: To explore the technical and clinical evaluation of ultrasound-derived fat fraction (UDFF) measurement in adult patients in whom fatty liver was suspected.

Materials and methods: In this prospective study, 41 participants were initially enrolled in our hospital between October 2022 and December 2022 and received UDFF assessment using Siemens ACUSON Sequoia system equipped with DAX transducer. UDFF measurement was performed three times to obtain UDFF values from each imaging location (V hepatic segment and VIII hepatic segment) per participant, and the depth (skin-to-capsule distance) was automatically measured. The echogenicity of liver tissue in B mode ultrasound (BMUS) was compared to the normal kidney tissue, and fatty liver was graded as mild (Grade 1), moderate (Grade 2), and severe (Grade 3). The median of the acquired overall median UDFF values was used for statistical analysis. All ultrasound examinations were performed by one of two radiologists (with 20 and 10 years of liver ultrasound imaging experience).

Results: Finally, UDFF measurement was successfully performed on 38 participants to obtain valid values, including 21 men with a median age of 40.0 years (interquartile range [IQR]: 23.0 - 58.5) and 17 women with a median age of 60.0 years (IQR: 29.5 - 67.0). Fatty liver was diagnosed by BMUS features in 47.4% (18/38) participants. Among all participants, the median UDFF value was 7.0% (IQR: 4.0 - 15.6). A significant difference in UDFF values was found between participants with fatty liver and without fatty liver (U = 7.0, P < 0.001), and UDFF values elevated as the grade of the fatty liver increased (P < 0.001). The median UDFF values from the three UDFF measurements obtained during each ultrasound examination showed excellent agreement (ICC = 0.882 [95% confidence interval: 0.833 - 0.919]). The Spearman correlation of UDFF values in different depths was moderate, with a rs value of 0.546 (P < 0.001). No significant differences in UDFF values were found between V hepatic segment and VIII hepatic segment (U = 684.5, P = 0.697).

Conclusions: UDFF provides a novel non-invasive imaging tool for hepatic steatosis assessment with excellent feasibility.

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利用超声波得出的脂肪分数分析肝脏脂肪变性：首次技术和临床评估

目的探讨对疑似脂肪肝的成年患者进行超声衍生脂肪分数（UDFF）测量的技术和临床评估：在这项前瞻性研究中，我院于 2022 年 10 月至 2022 年 12 月间首次招募了 41 名参与者，并使用配备 DAX 传感器的西门子 ACUSON Sequoia 系统进行了 UDFF 评估。UDFF测量共进行三次，以获得每位参与者每个成像位置（肝V段和肝VIII段）的UDFF值，并自动测量深度（皮肤到囊的距离）。将 B 模式超声（BMUS）中肝组织的回声性与正常肾组织进行比较，并将脂肪肝分为轻度（1 级）、中度（2 级）和重度（3 级）。统计分析采用获得的总体 UDFF 中值的中位数。所有超声检查均由两名放射科医生（分别拥有 20 年和 10 年肝脏超声成像经验）中的一位进行：最后，对 38 名参与者成功进行了 UDFF 测量，获得了有效值，其中包括 21 名男性，中位年龄为 40.0 岁（四分位间距 [IQR]：23.0 - 58.5），17 名女性，中位年龄为 60.0 岁（四分位间距 [IQR]：29.5 - 67.0）。47.4%的参与者（18/38）通过 BMUS 特征诊断出脂肪肝。在所有参与者中，UDFF 的中位值为 7.0%（IQR：4.0 - 15.6）。脂肪肝患者和非脂肪肝患者的 UDFF 值存在明显差异（U = 7.0，P 结论：UDFF 是一种新型的非内源性脂肪肝诊断方法：UDFF 为肝脏脂肪变性评估提供了一种新型的无创成像工具，具有极佳的可行性。

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来源期刊

Clinical hemorheology and microcirculation 医学-外周血管病

CiteScore

4.30

自引率

33.30%

发文量

170

期刊介绍： Clinical Hemorheology and Microcirculation, a peer-reviewed international scientific journal, serves as an aid to understanding the flow properties of blood and the relationship to normal and abnormal physiology. The rapidly expanding science of hemorheology concerns blood, its components and the blood vessels with which blood interacts. It includes perihemorheology, i.e., the rheology of fluid and structures in the perivascular and interstitial spaces as well as the lymphatic system. The clinical aspects include pathogenesis, symptomatology and diagnostic methods, and the fields of prophylaxis and therapy in all branches of medicine and surgery, pharmacology and drug research. The endeavour of the Editors-in-Chief and publishers of Clinical Hemorheology and Microcirculation is to bring together contributions from those working in various fields related to blood flow all over the world. The editors of Clinical Hemorheology and Microcirculation are from those countries in Europe, Asia, Australia and America where appreciable work in clinical hemorheology and microcirculation is being carried out. Each editor takes responsibility to decide on the acceptance of a manuscript. He is required to have the manuscript appraised by two referees and may be one of them himself. The executive editorial office, to which the manuscripts have been submitted, is responsible for rapid handling of the reviewing process. Clinical Hemorheology and Microcirculation accepts original papers, brief communications, mini-reports and letters to the Editors-in-Chief. Review articles, providing general views and new insights into related subjects, are regularly invited by the Editors-in-Chief. Proceedings of international and national conferences on clinical hemorheology (in original form or as abstracts) complete the range of editorial features.