The predictive value of MiR-221 in cancer chemoresistance: a systematic review and meta-analysis.

IF 2.9 3区医学 Q2 ONCOLOGY Expert Review of Anticancer Therapy Pub Date : 2023-07-01 Epub Date: 2023-06-05 DOI:10.1080/14737140.2023.2219451

Yuxi Liu, Jingwen Li, Junying Li, Han Yan, Bing Qiao, Yadan Wang, Yu Hu, Chunyan Sun

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Abstract

Background: Many studies have reported that microRNA-221 (miR-221) is abnormally expressed in various cancers, and there has not been a study to systematically analyze the association between miR-221 and chemoresistance in different cancers.

Methods: We systematically searched PubMed, Web of Science, Ovid, and Cochrane for relevant studies. The pooled odds ratios (ORs) and hazard ratios (HRs) with 95% confidence intervals (CIs) were used to estimate.

Results: A total of 30 studies with 1670 patients were enrolled in our study. Thirteen cancer types have been studied, and traditional chemotherapy, targeted drugs, endocrine therapy, chemoradiotherapy, and other treatments were used. High miR-221 expression was associated with poor chemotherapy response in most studies, and the meta-analysis confirmed this result (OR = 3.64, 95%CI: 1.73-7.62, p = 0.001). Besides, the higher level of miR-221 was related to shorter overall survival (OS) (HR = 2.16, 95%CI: 1.47-3.16, p < 0.001) and progression-free survival (PFS) (HR = 1.81, 95%CI: 1.51-2.16, p < 0.001) in patients after chemotherapy.

Conclusion: Our results highlight that high miR-221 expression has possible associations with chemoresistance and poor prognosis in multiple cancers. Further studies are needed to discover the molecular mechanisms underlying these associations to provide a solid evidence base for it being used as biomarkers of response to chemotherapeutic interventions in cancer.

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MiR-221对癌症化疗耐药性的预测价值：系统综述和荟萃分析。

背景：许多研究报道了微小RNA-221（miR-221）在各种癌症中的异常表达，目前还没有系统分析miR-221与不同癌症化疗耐药性之间关系的研究。方法：系统检索PubMed、Web of Science、Ovid和Cochrane的相关研究。使用95%置信区间（CI）的合并比值比（OR）和危险比（HR）进行估计。结果：共有30项研究，1670名患者参与了我们的研究。研究了13种癌症类型，使用了传统化疗、靶向药物、内分泌治疗、放化疗和其他治疗方法。在大多数研究中，miR-221的高表达与较差的化疗反应有关，荟萃分析证实了这一结果（OR = 3.64，95%可信区间：1.73-7.62，p = 0.001）。此外，miR-221水平越高，总生存期（OS）越短（HR = 2.16，95%可信区间：1.47-3.16，p p 结论：我们的研究结果强调，miR-221的高表达可能与多种癌症的化疗耐药性和不良预后有关。需要进一步的研究来发现这些关联的分子机制，为其被用作癌症化疗干预反应的生物标志物提供坚实的证据基础。

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来源期刊

Expert Review of Anticancer Therapy 医学-肿瘤学

CiteScore

5.10

自引率

3.00%

发文量

100

审稿时长

4-8 weeks

期刊介绍： Expert Review of Anticancer Therapy (ISSN 1473-7140) provides expert appraisal and commentary on the major trends in cancer care and highlights the performance of new therapeutic and diagnostic approaches. Coverage includes tumor management, novel medicines, anticancer agents and chemotherapy, biological therapy, cancer vaccines, therapeutic indications, biomarkers and diagnostics, and treatment guidelines. All articles are subject to rigorous peer-review, and the journal makes an essential contribution to decision-making in cancer care. Comprehensive coverage in each review is complemented by the unique Expert Review format and includes the following sections: Expert Opinion - a personal view of the data presented in the article, a discussion on the developments that are likely to be important in the future, and the avenues of research likely to become exciting as further studies yield more detailed results Article Highlights – an executive summary of the author’s most critical points.