Age-Related Prevalence of Open Ductus Arteriosus in Full-Term Newborns.

IF 2.6 3区医学 Q1 PEDIATRICS Neonatology Pub Date : 2023-01-01 DOI:10.1159/000529842

Anton Friis Mariager, Alberte Hammeken, Mikkel Malham, Anna Axelsson Raja, Anna Sellmer, Signe Levring Skjellerup, Raheel Altaf Raja, Johan Navne, Anne-Sophie Sillesen, Niels Vejlstrup, Henning Bundgaard, Kasper Karmark Iversen, Ester Garne, Dorthe Lisbeth Jeppesen

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Abstract

Background: The ductus arteriosus is part of the fetal circulation. Normally, the vessel closes during the cardiac transition. Delayed closure is associated with complications. The aim of this study was to evaluate the age-related prevalence of open ductus arteriosus in full-term neonates.

Methods: Echocardiograms were collected in the population study, the Copenhagen Baby Heart Study. The present study included full-term neonates with an echocardiogram performed within 28 days after birth. All echocardiograms were reviewed to assess ductus arteriosus patency.

Results: A total of 21,649 neonates were included. In neonates examined at day zero and day seven, an open ductus arteriosus was found in 36% and 0.6%, respectively. Beyond day seven, the prevalence remained stable at 0.6%.

Conclusion: More than one-third of full-term neonates had an open ductus arteriosus on the first day of life, declining rapidly within the first week and stabilizing below 1% after day seven.

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足月新生儿动脉导管开放性的年龄相关性患病率。

背景:动脉导管是胎儿循环的一部分。正常情况下，血管在心脏转换期间关闭。延迟闭合与并发症有关。本研究的目的是评估足月新生儿动脉导管开放性的年龄相关性。方法:收集人口研究、哥本哈根婴儿心脏研究的超声心动图。本研究包括出生后28天内进行超声心动图检查的足月新生儿。检查所有超声心动图以评估动脉导管通畅程度。结果:共纳入新生儿21649例。在第0天和第7天检查的新生儿中，分别有36%和0.6%的人发现动脉导管打开。第7天以后，患病率稳定在0.6%。结论:超过三分之一的足月新生儿在出生第一天出现动脉导管开放，在第一周内迅速下降，7天后稳定在1%以下。

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来源期刊

Neonatology 医学-小儿科

CiteScore

0.60

自引率

4.00%

发文量

审稿时长

6-12 weeks

期刊介绍： This highly respected and frequently cited journal is a prime source of information in the area of fetal and neonatal research. Original papers present research on all aspects of neonatology, fetal medicine and developmental biology. These papers encompass both basic science and clinical research including randomized trials, observational studies and epidemiology. Basic science research covers molecular biology, molecular genetics, physiology, biochemistry and pharmacology in fetal and neonatal life. In addition to the classic features the journal accepts papers for the sections Research Briefings and Sources of Neonatal Medicine (historical pieces). Papers reporting results of animal studies should be based upon hypotheses that relate to developmental processes or disorders in the human fetus or neonate.

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