Frequency of HER2 Expression, MMR Deficiency, and PI3KCA Mutation in Pretreated Surgical Specimens of Patients with Esophageal Squamous Cell Carcinoma in Iran Cancer Institute.

Q3 Medicine Iranian Journal of Pathology Pub Date : 2023-01-01 DOI:10.30699/IJP.2023.563358.2989

Samaneh Salarvand Farzaneh Bagheri, Mahsa Gholizadeh, Sima Sharifi, Pooneh Panahi, Ebrahim Esmati, Marzieh Lashkari, Amirmohsen Jalaeefar, Mohammad Shirkhoda, Reza Shahsiah, Reza Ghalehtaki

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Abstract

Background & objective: Iran is located in the esophageal cancer geographical belt. As multiple genetic alterations are responsible for the molecular pathogenesis of esophageal squamous cell cancer (ESCC), the role and frequency of HER2 expression, MMR deficiency, and PI3KCA mutation are not well defined.

Methods: We carried out HER2/neu expression, dMMR/MSI high, and PI3KCA mutation analysis in specimens of patients with ESCC. We accessed archival tissue blocks related to specimens of 68 ESCC cases at the time of surgery following neoadjuvant chemoradiation. These patients underwent surgery during 2013-2018 at the Cancer Institute of Iran affiliated with the Tehran University of Medical Sciences in Tehran.

Results: None of the patients showed HER2 expression, dMMR/MSI high, or PI3K mutations.

Conclusion: dMMR/MSI-H and PI3KCA mutation and HER2 expression may not be reliable andfrequent targets for systemic therapy in patients with esophageal SCC.

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伊朗癌症研究所食管鳞状细胞癌术前标本中HER2表达频率、MMR缺失和PI3KCA突变

背景与目的:伊朗地处食管癌地理带。由于多种遗传改变是食管鳞状细胞癌(ESCC)的分子发病机制，HER2表达、MMR缺陷和PI3KCA突变的作用和频率尚不明确。方法:对ESCC患者标本进行HER2/neu表达、dMMR/MSI高、PI3KCA突变分析。我们获取了68例ESCC病例在新辅助放化疗后手术时相关的档案组织块。这些患者于2013-2018年在德黑兰医学大学附属的伊朗癌症研究所接受了手术。结果:所有患者均未出现HER2表达、dMMR/MSI高或PI3K突变。结论:dMMR/MSI-H和PI3KCA突变和HER2表达可能不是食管鳞状细胞癌患者全身治疗的可靠和常见靶点。

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