The role of hyaluronan in endothelial glycocalyx and potential preventative lifestyle strategy with advancing age.

4区 生物学 Q4 Biochemistry, Genetics and Molecular Biology Current topics in membranes Pub Date : 2023-01-01 DOI:10.1016/bs.ctm.2023.02.006
Jisok Lim, Daniel Robert Machin, Anthony John Donato
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Abstract

The endothelial glycocalyx (EG) is a gel-like structure that forms a layer in between the surface of the endothelium and lumen. EG was once thought to be merely a structural support for the endothelium. However, in recent years, the importance of EG as a first line of defense and a key regulator to endothelial integrity has been illuminated. With advanced age, EG deterioration becomes more noticeable and at least partially associated with endothelial dysfunction. Hyaluronan (HA), one of the critical components of the EG, has distinct properties and roles to the maintenance of EG and endothelial function. Therefore, given the intimate relationship between the EG and endothelium during the aging process, HA may serve as a promising therapeutic target to prevent endothelial dysfunction.

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透明质酸在内皮糖萼中的作用及随年龄增长的潜在预防生活方式策略。
内皮糖萼(EG)是一种凝胶状结构,在内皮细胞表面和管腔之间形成一层。EG曾被认为仅仅是内皮细胞的结构支持。然而,近年来,EG作为第一道防线和内皮完整性的关键调节因子的重要性已经被阐明。随着年龄的增长,EG的恶化变得更加明显,至少部分与内皮功能障碍有关。透明质酸(HA)是EG的关键成分之一,在EG和内皮功能的维持中具有独特的性质和作用。因此,鉴于衰老过程中EG与内皮之间的密切关系,透明质酸可能成为预防内皮功能障碍的有希望的治疗靶点。
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来源期刊
Current topics in membranes
Current topics in membranes 生物-生化与分子生物学
CiteScore
3.50
自引率
0.00%
发文量
10
审稿时长
>12 weeks
期刊介绍: Current Topics in Membranes provides a systematic, comprehensive, and rigorous approach to specific topics relevant to the study of cellular membranes. Each volume is a guest edited compendium of membrane biology.
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