The role of hyaluronan in endothelial glycocalyx and potential preventative lifestyle strategy with advancing age.

4区 生物学 Q4 Biochemistry, Genetics and Molecular Biology Current topics in membranes Pub Date : 2023-01-01 Epub Date: 2023-03-10 DOI:10.1016/bs.ctm.2023.02.006
Jisok Lim, Daniel Robert Machin, Anthony John Donato
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引用次数: 0

Abstract

The endothelial glycocalyx (EG) is a gel-like structure that forms a layer in between the surface of the endothelium and lumen. EG was once thought to be merely a structural support for the endothelium. However, in recent years, the importance of EG as a first line of defense and a key regulator to endothelial integrity has been illuminated. With advanced age, EG deterioration becomes more noticeable and at least partially associated with endothelial dysfunction. Hyaluronan (HA), one of the critical components of the EG, has distinct properties and roles to the maintenance of EG and endothelial function. Therefore, given the intimate relationship between the EG and endothelium during the aging process, HA may serve as a promising therapeutic target to prevent endothelial dysfunction.

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透明质酸在内皮细胞糖萼中的作用以及随着年龄增长的潜在预防性生活方式策略。
内皮糖萼(EG)是一种凝胶状结构,在内皮表面和管腔之间形成一层。人们曾一度认为 EG 只是内皮的结构支撑。然而,近年来,EG 作为第一道防线和内皮完整性的关键调节因子的重要性已被揭示。随着年龄的增长,EG 的退化越来越明显,至少部分与内皮功能障碍有关。透明质酸(HA)是 EG 的关键成分之一,在维持 EG 和内皮功能方面具有独特的性质和作用。因此,鉴于衰老过程中 EG 与内皮之间的密切关系,HA 可作为预防内皮功能障碍的治疗靶点。
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来源期刊
Current topics in membranes
Current topics in membranes 生物-生化与分子生物学
CiteScore
3.50
自引率
0.00%
发文量
10
审稿时长
>12 weeks
期刊介绍: Current Topics in Membranes provides a systematic, comprehensive, and rigorous approach to specific topics relevant to the study of cellular membranes. Each volume is a guest edited compendium of membrane biology.
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