Altered serum levels of platelet-derived growth factor receptor β and cluster of differentiation 13 suggest a role for pericytes in West syndrome

IF 1.4 4区医学 Q4 CLINICAL NEUROLOGY Brain & Development Pub Date : 2023-10-01 DOI:10.1016/j.braindev.2023.05.005

Yusuke Watanabe , Gaku Yamanaka , Shinichiro Morichi , Kanako Hayashi , Shinji Suzuki , Mika Takeshita , Natsumi Morishita , Yu Ishida , Shingo Oana , Fuyuko Takata , Hisashi Kawashima

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Abstract

Background

Pericytes play a role in the maintenance of the blood–brain barrier and neuroinflammation, attracting attention as to whether they are also involved in the pathogenesis of epilepsy. This study aimed to explore the relationship between West syndrome and pericytes.

Methods

Eighteen Japanese pediatric West syndrome patients and nine controls aged 2 years or younger were retrospectively enrolled in this study. We assessed the serum levels of pericyte markers, serum PDGFRβ (platelet-derived growth factor receptor β), CD13 (aminopeptidase N), and 27 cytokines in 17 pediatric patients with West syndrome and the control group.

Results

Patients with West syndrome exhibited significantly increased CD13 and decreased PDGFRβ levels, compared with controls but not serum cytokine levels. These values did not differ significantly between symptomatic and idiopathic West syndrome.

Conclusion

Pericytes might be implicated in the pathogenesis of West syndrome.

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血小板衍生生长因子受体β和分化簇13的血清水平改变表明周细胞在West综合征中的作用

背景周细胞在维持血脑屏障和神经炎症中发挥作用，是否也参与癫痫的发病机制引起了人们的关注。本研究旨在探讨West综合征与周细胞的关系。方法对18例日本儿童West综合征患者和9例2岁及以下的对照组进行回顾性研究。我们评估了17名West综合征患儿和对照组的周细胞标志物、血清PDGFRβ（血小板衍生生长因子受体β）、CD13（氨基肽酶N）和27种细胞因子的血清水平。结果与对照组相比，West综合征患者的CD13水平显著升高，PDGFRβ水平显著降低，但血清细胞因子水平没有降低。这些数值在症状性和特发性West综合征之间没有显著差异。结论周细胞可能参与West综合征的发病机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Brain & Development 医学-临床神经学

CiteScore

3.60

自引率

0.00%

发文量

153

审稿时长

50 days

期刊介绍： Brain and Development (ISSN 0387-7604) is the Official Journal of the Japanese Society of Child Neurology, and is aimed to promote clinical child neurology and developmental neuroscience. The journal is devoted to publishing Review Articles, Full Length Original Papers, Case Reports and Letters to the Editor in the field of Child Neurology and related sciences. Proceedings of meetings, and professional announcements will be published at the Editor''s discretion. Letters concerning articles published in Brain and Development and other relevant issues are also welcome.

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