Characteristics of Meningococcal Invasive Disease in Neonates and Virulence of the Corresponding Isolates.

IF 2.6 3区医学 Q1 PEDIATRICS Neonatology Pub Date : 2023-01-01 DOI:10.1159/000530151

Melissa Beggaz, Tamazoust Guiddir, Eva Hong, Ala-Eddine Deghmane, Muhamed-Kheir Taha

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Abstract

Background: The highest incidence of invasive meningococcal disease (IMD) is observed in infants. However, its prevalence in neonates (≤28 days of age) and the characteristics of the corresponding isolates are less described. This report aimed to analyze meningococcal isolates from neonates.

Methods: We first screened the database of the national reference center for meningococci in France for confirmed neonatal IMD cases between 1999 and 2019. We then performed whole-genome sequencing on all cultured isolates, and we evaluated their virulence in a mouse model.

Results: Fifty-three neonatal cases of IMD (mainly bacteremia) were identified (50 culture-confirmed cases and 3 PCR-confirmed cases) of a total of 10,149 cases (0.5%) but represented 11% of cases among infants of under 1 year of age. Nine cases (17%) occurred among neonates of 3 days of age and younger (early onset). The neonate isolates were often of serogroup B (73.6%) and belonged to the clonal complex CC41/44 (29.4%) with at least 68.5% of coverage by vaccines against serogroup B isolates. The neonatal isolates were able to infect mice although to variable levels.

Conclusion: IMD in neonates is not rare and can be of early or late onsets suggesting that anti-meningococcal vaccination can target women planning to have a baby.

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新生儿脑膜炎球菌侵袭性疾病的特点及其分离株的毒力。

背景:婴儿是侵袭性脑膜炎球菌病(IMD)发病率最高的人群。然而，其在新生儿(≤28日龄)中的流行率和相应分离株的特征描述较少。本报告旨在分析新生儿脑膜炎球菌分离株。方法:我们首先筛选法国国家脑膜炎球菌参考中心数据库中1999年至2019年确诊的新生儿IMD病例。然后我们对所有培养的分离株进行了全基因组测序，并在小鼠模型中评估了它们的毒力。结果:在10149例(0.5%)新生儿中发现53例IMD(主要是菌血症)(培养确诊50例，pcr确诊3例)，但占1岁以下婴儿病例的11%。9例(17%)发生在3日龄及以下的新生儿中(早发)。新生儿分离株通常为B血清组(73.6%)，属于克隆复合体CC41/44(29.4%)，针对B血清组分离株的疫苗覆盖率至少为68.5%。新生儿分离株能够感染小鼠，尽管感染程度不同。结论:新生儿IMD并不罕见，可早发或晚发，提示抗脑膜炎球菌疫苗接种可针对计划生育的妇女。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neonatology 医学-小儿科

CiteScore

0.60

自引率

4.00%

发文量

审稿时长

6-12 weeks

期刊介绍： This highly respected and frequently cited journal is a prime source of information in the area of fetal and neonatal research. Original papers present research on all aspects of neonatology, fetal medicine and developmental biology. These papers encompass both basic science and clinical research including randomized trials, observational studies and epidemiology. Basic science research covers molecular biology, molecular genetics, physiology, biochemistry and pharmacology in fetal and neonatal life. In addition to the classic features the journal accepts papers for the sections Research Briefings and Sources of Neonatal Medicine (historical pieces). Papers reporting results of animal studies should be based upon hypotheses that relate to developmental processes or disorders in the human fetus or neonate.

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