Advances in the development of amorphous solid dispersions: The role of polymeric carriers

IF 10.7 1区 医学 Q1 PHARMACOLOGY & PHARMACY Asian Journal of Pharmaceutical Sciences Pub Date : 2023-07-01 DOI:10.1016/j.ajps.2023.100834
Jie Zhang , Minshan Guo , Minqian Luo , Ting Cai
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引用次数: 4

Abstract

Amorphous solid dispersion (ASD) is one of the most effective approaches for delivering poorly soluble drugs. In ASDs, polymeric materials serve as the carriers in which the drugs are dispersed at the molecular level. To prepare the solid dispersions, there are many polymers with various physicochemical and thermochemical characteristics available for use in ASD formulations. Polymer selection is of great importance because it influences the stability, solubility and dissolution rates, manufacturing process, and bioavailability of the ASD. This review article provides a comprehensive overview of ASDs from the perspectives of physicochemical characteristics of polymers, formulation designs and preparation methods. Furthermore, considerations of safety and regulatory requirements along with the studies recommended for characterizing and evaluating polymeric carriers are briefly discussed.

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非晶固体分散体的研究进展:聚合物载体的作用
无定形固体分散体(ASD)是递送难溶性药物的最有效方法之一。在ASD中,聚合物材料充当药物在分子水平上分散的载体。为了制备固体分散体,有许多具有各种物理化学和热化学特性的聚合物可用于ASD制剂。聚合物的选择非常重要,因为它影响ASD的稳定性、溶解度和溶解速率、制造工艺和生物利用度。这篇综述文章从聚合物的物理化学特性、配方设计和制备方法等方面对ASD进行了全面综述。此外,还简要讨论了安全性和监管要求的考虑因素,以及为表征和评估聚合物载体而推荐的研究。
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来源期刊
Asian Journal of Pharmaceutical Sciences
Asian Journal of Pharmaceutical Sciences Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science
CiteScore
18.30
自引率
2.90%
发文量
11
审稿时长
14 days
期刊介绍: The Asian Journal of Pharmaceutical Sciences (AJPS) serves as the official journal of the Asian Federation for Pharmaceutical Sciences (AFPS). Recognized by the Science Citation Index Expanded (SCIE), AJPS offers a platform for the reporting of advancements, production methodologies, technologies, initiatives, and the practical application of scientific knowledge in the field of pharmaceutics. The journal covers a wide range of topics including but not limited to controlled drug release systems, drug targeting, physical pharmacy, pharmacodynamics, pharmacokinetics, pharmacogenomics, biopharmaceutics, drug and prodrug design, pharmaceutical analysis, drug stability, quality control, pharmaceutical engineering, and material sciences.
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