The Physical Compatibility of Glycopyrrolate and Rocuronium.

Q3 Medicine Anesthesia progress Pub Date : 2023-06-01 DOI:10.2344/anpr-69-04-02

Austen L Weeks, John Sotos, Bryce Woolsey, William M Johnston, Bryant W Cornelius

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Abstract

Objective: Scientific evidence has rarely, if at all, been reported in the literature demonstrating analytical confirmation of the physical compatibility and stability of glycopyrrolate and rocuronium combined. The purpose of this experiment was to determine if glycopyrrolate and rocuronium are physically compatible.

Methods: Glycopyrrolate and rocuronium were combined in various containers, observed over a 60-minute period, and compared against positive and negative controls. Measured metrics included color change, precipitate formation, Tyndall beam test, turbidity, and pH. Statistical analyses were used to assess significance of data trends.

Results: The combination of glycopyrrolate and rocuronium did not result in any color change, precipitate formation, a positive Tyndall beam test, or a significantly positive turbidity and did not result in any significant change in pH, regardless of container.

Conclusion: Per the protocol used in this study, glycopyrrolate and rocuronium were determined to be physically compatible.

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甘罗罗酸盐与罗库溴铵的物理相容性。

目的:文献中很少有科学证据，如果有的话，证明分析证实甘罗罗酸盐和罗库溴铵合用的物理相容性和稳定性。本实验的目的是确定甘罗酸盐和罗库溴铵是否具有物理相容性。方法:将甘罗酸酯和罗库溴铵分别装于不同的容器中，观察60分钟，并与阳性和阴性对照进行比较。测量指标包括颜色变化、沉淀形成、廷德尔光束试验、浊度和ph值。统计分析用于评估数据趋势的显著性。结果:甘罗酸盐与罗库溴铵联合用药，无论何种容器，均未见颜色变化、沉淀形成、廷德尔梁试验阳性、浊度明显阳性，pH值未见明显变化。结论:根据本研究使用的方案，确定了甘罗罗酸盐和罗库溴铵的物理相容性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Anesthesia progress Medicine-Medicine (all)

CiteScore

0.90

自引率

0.00%

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期刊介绍： Anesthesia Progress is a peer-reviewed journal and the official publication of the American Dental Society of Anesthesiology. The journal is dedicated to providing a better understanding of the advances being made in the art and science of pain and anxiety control in dentistry.

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