Atypical Case of POEMS Presented as Demyelinating Polyneuropathy With Motor Conduction Block.

Abstract

between the virus and the human heat shock proteins 90 and 605 was incriminated in post–COVID-19 GBS. As no data exist for COVID-19 vaccine, we found 2 possible mechanisms involved in postinfluenza vaccine GBS: the synergistic effects of endotoxin and vaccine-induced autoimmunity.6 A genetic susceptibility such as certain major histocompatibility complex alleles predisposes individuals to autoimmunity.7 Other immune secondary effects were reported after AstraZeneca vaccination such as immune thrombocytopenia mediated by platelet-activating antibodies2 or transverse myelitis found in 2 patients in the clinical trial.8 For a fuller understanding of the causes of GBS and its possible relationship with the novel COVID-19 vaccines, additional research is required. However, the relative small incidence of postvaccine GBS and the reduction of the severe acute respiratory syndrome coronavirus 2 infection rate in the vaccinated population suggest that the vaccination benefits outweigh the risks.