The Health, Aging, and Body Composition (Health ABC) Study-Ground-Breaking Science for 25 Years and Counting.

IF 4.3 2区医学 Q1 GERIATRICS & GERONTOLOGY Journals of Gerontology Series A-Biological Sciences and Medical Sciences Pub Date : 2023-10-28 DOI:10.1093/gerona/glad167

Anne B Newman, Marjolein Visser, Stephen B Kritchevsky, Eleanor Simonsick, Peggy M Cawthon, Tamara B Harris

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Abstract

Background: The Health, Aging, and Body Composition Study is a longitudinal cohort study that started just over 25 years ago. This ground-breaking study tested specific hypotheses about the importance of weight, body composition, and weight-related health conditions for incident functional limitation in older adults.

Methods: Narrative review with analysis of ancillary studies, career awards, publications, and citations.

Results: Key findings of the study demonstrated the importance of body composition as a whole, both fat and lean mass, in the disablement pathway. The quality of the muscle in terms of its strength and its composition was found to be a critical feature in defining sarcopenia. Dietary patterns and especially protein intake, social factors, and cognition were found to be critical elements for functional limitation and disability. The study is highly cited and its assessments have been widely adopted in both observational studies and clinical trials. Its impact continues as a platform for collaboration and career development.

Conclusions: The Health ABC provides a knowledge base for the prevention of disability and promotion of mobility in older adults.

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健康、衰老和身体成分（健康ABC）研究突破性科学25年和计数。

背景：健康、衰老和身体成分研究是一项始于25年前的纵向队列研究。这项突破性的研究检验了关于体重、身体成分和与体重相关的健康状况对老年人意外功能限制的重要性的具体假设。方法：叙述性综述，分析辅助研究、职业奖项、出版物和引文。结果：该研究的关键发现表明，身体成分作为一个整体，包括脂肪和瘦体重，在致残途径中的重要性。肌肉的强度和成分是定义少肌症的一个关键特征。饮食模式，尤其是蛋白质摄入、社会因素和认知是导致功能限制和残疾的关键因素。该研究被高度引用，其评估已在观察性研究和临床试验中广泛采用。作为一个合作和职业发展的平台，它的影响力仍在继续。结论：健康ABC为预防老年人残疾和促进老年人行动能力提供了知识基础。

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来源期刊

Journals of Gerontology Series A-Biological Sciences and Medical Sciences 医学-老年医学

CiteScore

10.00

自引率

5.90%

发文量

233

审稿时长

3-8 weeks

期刊介绍： Publishes articles representing the full range of medical sciences pertaining to aging. Appropriate areas include, but are not limited to, basic medical science, clinical epidemiology, clinical research, and health services research for professions such as medicine, dentistry, allied health sciences, and nursing. It publishes articles on research pertinent to human biology and disease.